Ginkgolide B
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Ginkgolide B 속성
- 녹는점
- 280°C (dec.)
- 알파
- D24 -52.6° (c = 1 in ethanol)
- 끓는 점
- 762.4±60.0 °C(Predicted)
- 밀도
- 1?+-.0.1 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 용해도
- DMSO(최대 40mg/ml) 또는 에탄올(최대 10mg/ml)에 용해됩니다.
- 산도 계수 (pKa)
- pKa1 7.14; pKa2 8.60; pKa3 11.89(at 25℃)
- 색상
- 하얀색
- 수용성
- DMSO에 용해됩니다. 물과 에탄올에 약간 용해됨
- BRN
- 4727611
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- InChIKey
- SQOJOAFXDQDRGF-MMQTXUMRSA-N
- SMILES
- [C@@]12(O)[C@]34C(=O)O[C@@H]5C[C@@H](C(C)(C)C)C6([C@@H](O)C(=O)O[C@@]6([H])O3)C45[C@H](O)[C@]1([H])OC(=O)[C@H]2C
- LogP
- 2.070 (est)
- CAS 데이터베이스
- 15291-77-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
Ginkgolide B C화학적 특성, 용도, 생산
개요
Ginkgo biloba is a perennial tree belonging to Ginkgoaceae (Ginkgo biloba L., Yin Xing). Its seeds, also known as ginkgo, have a long history of application in traditional medicine for its medicinal value. With promoting blood circulation by removing blood stasis, Ginkgo biloba has a long history of its application in traditional Chinese medicineIn recent years, it has been widely used in the treatment of cerebral ischemic diseases. After further study, it was found that the effective component is ginkgolide compound, which laid the foundation for the development of small molecule drugs.
화학적 성질
White Crystalline Solid물리적 성질
Appearance: ginkgolide B is a white powder. Solubility: weighed 0.98?g and dissolves in 1L water (calculation). Melting point: the compound melts at 280? °C (calculation)역사
The leaf of Ginkgo biloba is sweet, bitter, astringent, and mild. With activating blood circulation to remove blood stasis, dredging collaterals, relieving pain, and asthma, it is applied for treating blood stasis, chest pain, stroke, lung deficiency cough, and hyperlipidemia.As early as in the 1930s, scientists began to study ginkgo and harvest a variety of ginkgolide . Ginkgolide B was isolated and its structure illustrated by Wan Shan et?al. in 1967. Subsequently, it was synthesized by Corey et?al. in 1988. The preparation of effective components of Ginkgo biloba has been listed at home and abroad with development.
The Ginkgo biloba extract consisting of ticlopidine is widely used in overseas market for the treatment of cerebral infarction. Intravenous injection of ginkgolide B is applied for the treatment of inflammation, but the project has been in the state, and there is no progress in it for many years. In addition, whether other extract of Ginkgo biloba can be used for the treatment of stable angina, cognitive impairment is still in preclinical research status.
용도
Ginkgolide B is used as a potent PAF-R antagonist. Ginkgolide B speeds up PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. Additionally, this compound has been reported to inhibit neutrophil degranulation in vitro. Inhibits superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.Indications
The injection consists of multiple components, and there are three kinds of substance mainly in diterpene ginkgolides meglumine injection. It promotes blood circulation by removing blood stasis and activates the channels and collaterals for cerebral ischemia treatment.생물학적 활성
Platelet-activating factor (PAF) receptor antagonist (K i = 1.3 μ M). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo .Pharmacology
Ginkgolide B has a variety of pharmacological effects, mainly in cardiovascular and cerebrovascular protection and neuroprotection. On the one hand, with the strongest activity in nature, the platelet-activating factor (PAF) receptor antagonist is recognized by the public . PAF can inhibit the downstream inflammatory cascade for anti-inflammatory. It also can alleviate cerebral infraction volume and cerebral edema induced by cerebral ischemia among the animal model of cerebral ischemia reperfusion through unknown mechanism. By inhibiting NF-κB and TNF-α, the apoptosis of nerve cell can be alleviated. The compound protects the abdominal cavity and intestinal tract by inhibiting release of neutrophil chemotactic protein by macrophage.Clinical Use
Oral and injection preparations are applied widely in clinical therapy. Made in oral preparation, flavonoids are the main component of raw material. There are little chemical compounds in injection, and ginkgolides are the main component whose content is different from each other. Listed ginkgolide injection is applied for ischemia stroke formed by blood stasis with promoting blood circulation by removing blood stasis and clearing and activating the channels and collaterals. Compared with Shuxuening injection in clinical trials, ginkgolides injection is consistent in improving indicators effect, such as protection in nerve injury and others.Ginkgolide B 준비 용품 및 원자재
원자재
준비 용품
Ginkgolide B 공급 업체
글로벌( 325)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 |
gao490372054@gamil.com | China | 1250 | 58 |
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 |
13119157289@163.com | China | 2971 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 |
sales@dolonchem.com | CHINA | 2972 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Ginkgolide B 관련 검색:
(S)-(+)-판토락톤 D-펜토락톤 (+/-)-2-하이드록시-3,3-다이메틸-감마-뷰틸로락톤
GINKGOLIDE C,1,7-DIHYDROXY-GINKGOLIDE A
GINKGOLIDE A, GINKGO BILOBA L,GINKGOLIDE A FROM GINKGO LEAVES,ginkgolide a from ginkgo biloba leaves,GINKGOLIDE A
GINKGOLIDE J
Ginkgolic acid
GINKGETIN
Ginkgolide K
Ethyl 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzene Sulfonamide Carbamate
Ginsenoside Re
Ginsenoside Rb1
Ginsenoside Rg1
Ginsenoside Rc
6-pentadecylsalicylic acid
Ginkgolic Acid C17:1
Ginkgolic Acid C17:2
Ginkgolides(90%)