MURISTERONE A

MURISTERONE A 구조식 이미지
카스 번호:
38778-30-2
상품명:
MURISTERONE A
동의어(영문):
MURA;Muristerone;MURISTERONE A;Ecdysonic sterol;MURISTERONE A(P);MURISTERONE A USP/EP/BP;MURISTERONE A, IPOMOEA SPP;5B, 7-CHOLESTENE-2B,3B,5A,11A,14,20,22-HEPTOL-6-ONE;2B,3B,5A,11A,14,20,22-HEPTAHYDROXY-5B-7-CHOLESTEN-6-ONE;2β,3β,5β,11α,14α,20R,22R-Heptahydroxycholest-7-en-6-one
CBNumber:
CB3781616
분자식:
C27H44O8
포뮬러 무게:
496.63
MOL 파일:
38778-30-2.mol

MURISTERONE A 속성

끓는 점
707.2±60.0 °C(Predicted)
밀도
1.33±0.1 g/cm3(Predicted)
저장 조건
−20°C
용해도
DMSO에 용해됨
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
11.78±0.70(Predicted)
색상
하얀색

안전

WGK 독일 3

MURISTERONE A C화학적 특성, 용도, 생산

개요

Muristerone A is a natural analog of 20-hydroxyecdysone . It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A is used as an agonist in ecdysone-inducible gene expression systems in mammalian cells. However, it inhibits apoptosis in the human colon carcinoma cell line RKO by inducing the upregulation of Bcl-xL, suggesting limitations in its use in certain types of studies.

용도

Muristerone A, an ecdysteroid, is widely used for the induction of ecdysteroid-dependent transcription in mammalian cells.

생물학적 활성

Ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.

MURISTERONE A 준비 용품 및 원자재

원자재

준비 용품


MURISTERONE A 공급 업체

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