디아실글리세롤키나제억제제II
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디아실글리세롤키나제억제제II 속성
- 녹는점
- 228-230 °C
- 끓는 점
- 637.1±65.0 °C(Predicted)
- 밀도
- 1.36±0.1 g/cm3(Predicted)
- 저장 조건
- -20°C
- 용해도
- 0.1M HCl: 약간 용해됨
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 11.24±0.20(Predicted)
- 색상
- 옅은 노랑
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
디아실글리세롤키나제억제제II C화학적 특성, 용도, 생산
개요
R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate. DGK-α inhibition with R-59-949 increases diacylglycerol-dependent PKC activity, serotonin secretion, and aggregation of thrombin-stimulated platelets. R-59-949 inhibits DGK-α activity induced by platelet-derived growth factor (PDGF) in intact vascular smooth muscle cells (VSMCs). It inhibits high K+- and glucose-induced insulin secretion in MIN6 pancreatic β-cells in a dose-dependent manner. In vivo, administration of R-59-949 prevents retinal neovascularization in a mouse model of oxygen-induced retinopathy.용도
Diacylglycerol Kinase Inhibitor II has been used to determine tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). It has also been used to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells.Biochem/physiol Actions
Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.디아실글리세롤키나제억제제II 준비 용품 및 원자재
원자재
준비 용품
디아실글리세롤키나제억제제II 공급 업체
글로벌( 47)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32686 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; |
laboratory@coreychem.com | China | 30255 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9634 | 58 |
Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 |
isunpharm@qq.com | China | 4428 | 55 |
Finetech Industry Limited | 027-87465837 19945049750 |
sales@finetechnology-ind.com | China | 9633 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9709 | 58 |
디아실글리세롤키나제억제제II 관련 검색:
4-Fluorostyrene
N-(2-Aminoethyl)piperidine
4-[(4-Fluorophenyl)methylene]piperidine
4,4'-Difluorodiphenylmethane
1-Fluoro-4-(1-methylethenyl)benzene
1-BENZOYL-2-THIOUREA
4-(DIPHENYLMETHYLENE)PIPERIDINE
1-Methyl-4-methylene-piperidine
3-ETHYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE
2-AMINO-N,N-DIMETHYL-BENZAMIDE
N-ETHYL-2-PIPERIDIN-1-YLETHANAMINE
N-BENZYL-N-METHYLTHIOUREA
METHYL-(2-PIPERIDIN-1-YL-ETHYL)-AMINE
N,N-DIETHYLTHIOUREA
1-(2-PIPERIDINOETHYL)-2-THIOUREA
1,1-BIS(4-FLUOROPHENYL)-1-BUTENE
DIACYLGLYCEROL KINASE INHIBITOR II
N-METHYL-N-(2-METHYLAMINO-ETHYL)-BENZAMIDE