암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)
발암성 물질
구분 2
경고
P201, P202, P281, P308+P313, P405,P501
H372
장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴
특정 표적장기 독성 - 반복 노출
구분 1
위험
P260, P264, P270, P314, P501
H411
장기적 영향에 의해 수생생물에 유독함
수생 환경유해성 물질 - 만성
구분 2
예방조치문구:
P201
사용 전 취급 설명서를 확보하시오.
P202
모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P260
분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P264
취급 후에는 손을 철저히 씻으시오.
P264
취급 후에는 손을 철저히 씻으시오.
P270
이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P280
보호장갑/보호의/보안경/안면보호구를 착용하시오.
P281
요구되는 개인 보호구를 착용하시오
P305+P351+P338
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313
노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P314
불편함을 느끼면 의학적인 조치·조언을 구하시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
Atorvastatin calcium C화학적 특성, 용도, 생산
개요
Lipitor was launched in Canada, the Netherlands, the UK and the US as an
orally-active hypocholesterolemic agent. It was the first pharmaceutical product ever
to attain over one billion dollars in sales in its first year. It can be synthesized by a
number of routes but the most efficient involves the Paal-Knorr reaction of an
acetonide protected dihydroxy amino ester and a diaryl phenylacetamide diketone.
Lipitor is a liver selective, reversible competitive inhibitor of HMG-CoA reductase, the
rate limiting step in cholesterol biosynthesis. Lipitor monotherapy resulted in a
reduction of LDL cholesterol by up to 60%. Lipitor is about 2-4 times more potent, on
a dosage basis, than Simvastatin. The superior properties of Lipitor can be attributed
to its greater uptake and longer duration of action in the liver. In addition to its effects
on cholesterol, Lipitor is also effective in lowering triglycerides. While the mechanism
is not clear, two theories proposed are: a) the decrease in cholesterol causes a
concomitant increase in hepatic LDL-receptor activity (mostly B and E type) which
results in a decrease in triglycerides through an increase in binding of triglycerides to
VLDL and LDL, and b) the decreased level of cholesterol impairs VLDL transport of
triglycerides.
화학적 성질
White Crystalline Powder
용도
A selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia
정의
ChEBI: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
생물학적 활성
Potent HMG-CoA reductase inhibitor (IC 50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.
