Oritavancin diphosphate is a glycopeptide analog related to the
vancomycin class of antibiotics that inhibits the transpeptidase
and transglycosylation steps of bacterial peptidoglycan cell-wall
synthesis. The compound was discovered and initially developed
by Eli Lilly and Co. The development of the compound was
sold to Intermune and then to Targanta which was acquired by
The Medicines Company who achieved approval of the drug by
the US FDA for the treatment of acute bacterial skin and skin-structure
infections caused by gram-positive bacteria. It is also
approved for the treatment of methicillin-resistant Staphylococcus
aureus (MRSA) infections.
ChEBI: A phosphate salt obtained by combining oritavancin with two molar equivalents of phosphoric acid. Used for the treatment of acute bacterial skin and skin structure infections caused or suspected to be caused by susceptible isolates of designated Gram-posit
ve microorganisms.
