Oxamic acid sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis. Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells.
화학적 성질
white crystalline powder
용도
Oxamic acid sodium salt is a lactate dehydrogenase (LDH) inhibitor. It is a suitable compound to investigate cancer cells that utilize the glycolytic pathway.This compound is suitable for lactate dehydrogenase (LDH) related research. It can be used as an inhibitor of gluconeogenesis useful for anticancer research.
주요 응용
Sodium oxamate, an inhibitor of LDH-C4, prevented the AR induced by lysophosphatidylcholine (LPC) or NADH. Oxamic acid sodium salt is an lactic acid dehydrogenase. Sperm suspension and cytosol fraction activities were inhibited by sodium oxamate. As cancer cells are often dependent on glycolysis for ATP production, sodium oxamate has implications as an anticancer compound.
Biochem/physiol Actions
Sodium oxamate influences the fatty acid metabolism. It might be useful for the treatment of diabetes.
