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Varenicline

Varenicline 구조식 이미지

카스 번호:: 249296-44-4

상품명:: Varenicline

동의어(영문):: Chantix;Varenciline;10-tetrahydro-;7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline;(1R,12S)-5,8,14-triazatetracyclo[10.3.1.0^{2,11}.0^{4,9}]hexadeca-2,4(9),5,7,10-pentaene;CS-861;Hsdb 7591;Cp 526555;Vareniclene;VARENICLINE

CBNumber:: CB61011764

분자식:: C13H13N3

포뮬러 무게:: 211.26

MOL 파일:: 249296-44-4.mol

속성

안전

용도

공급 업체 180

Varenicline 속성

녹는점: 138.5 °C

끓는 점: 400.6±40.0 °C(Predicted)

밀도: 1.247±0.06 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMSO에 용해됨

물리적 상태: 가루

산도 계수 (pKa): 9.60±0.20(Predicted)

BCS Class: 1

안정성: 흡습성

안전

유해 물질 데이터	249296-44-4(Hazardous Substances Data)

Varenicline C화학적 특성, 용도, 생산

개요

Varenicline, a partial agonist of the a4b2 nicotinic receptor, is a first-in-class drug launched by Pfizer as an aid to smoking cessation treatment. Varenicline exhibits dual action by decreasing craving and withdrawal symptoms, and by decreasing the reinforcement associated with smoking. The addictive properties of nicotine are thought to be mediated in part through its action as an agonist at α4β2 neuronal nicotinic acetylcholine receptors (nAChRs). Activation of α4β2 receptors by nicotine increases the release of dopamine in the mesolimbic system, an effect that is shared by most drugs of abuse. As nicotine levels decrease, dopamine levels decline, which in turn stimulates the urge to smoke. Additionally, a reduced dopaminergic tone due to abstinence from smoking stimulates craving and the withdrawal syndrome. A partial agonist of α4β2 receptors such as varenicline is expected to elicit a moderate and sustained increase in dopamine levels to relieve craving and withdrawal symptoms. In addition, by competitively binding to a4b2 receptors and inhibiting nicotineinduced dopaminergic activation, a partial agonist could attenuate the pharmacologic reward associated with smoking.

용도

Varenicline is a useful medication for smoking cessation.

정의

ChEBI: An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.

Varenicline 준비 용품 및 원자재

원자재

준비 용품

Varenicline tartrate

Varenicline 공급 업체

글로벌( 180)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Casorganics US Corp	+17326109938	sales@casorganics.com	CHINA	174	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58

Varenicline 관련 검색:

피라진아마이드 테트라메틸피라진 Sulfachoropyrazine sodium Glipizide Bivalirudin Norepinephrine Varenicline tartrate 7,8,9,10-Tetrahydro-8-(trifluoroacetyl)-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (N-(Trifluoroacetyl)varenicline) 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Tetrahydro Varenicline