Omethoate is a systemic insecticide used for the control of (mostly)
sucking insects and mites in a wide variety of crops.
색상 색인 번호
Contact dermatitis from omethoate-dimethoxon is rare.
신진 대사 경로
Omethoate is the P=O analogue (oxon) of dimethoate. Dimethoate is
metabolised via oxidative desulfuration to omethoate which is the active
anti-acetylcholinesterase metabolite. This biotransformation occurs in all
media: hence the metabolic pathways of both compounds have much in
common. However, degradative pathways acting directly on dimethoate
such as O-demethylation, N-demethylation and hydrolysis of the amide
function mean that the balance between activation and degradative
metabolism will influence their respective selective toxicities. In mammals
there are two main routes of degradation: (i) glutathione transferase
mediated O-demethylation (ii) hydrolysis to N-methylthioglycolamide
which is S-methylated by S-adenosylmethionine and subsequently
thiooxidised. In soil and plants the N-methylthioglycolamide moiety
formed from the hydrolysis of omethoate undergoes a complex series
of C1, C2 and C3 biotransformations ultimately leading to oxalate and
citrate respectively and total degradation to C02. The information
reported below is derived largely from an evaluation prepared by the
UK MAFF Pesticide Safety Directorate (PSD, 1993).
신진 대사
Orally administered omethoate to rats is
rapidly metabolized and excreted in the urine; the main
metabolites are O-demethylomethoate and N-methyl-2-
methylsulfinylacetamide. O-Demethylation and hydrolysis
of the P?S bond are main degradation routes both in
mammals and plants. Omethoate is rapidly degraded in
soils with DT50 of a few days.
