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NFPA 704
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4-Amino-4H-1,2,4-triazole C화학적 특성, 용도, 생산
화학적 성질
white to off-white or beige crystalline powder
용도
1,2,4-Triazol-4-amine is an intermediate used to prepare potent, selective, and orally active cyclooxygenase-?2 inhibitors. It is also used to synthesize hydroxyphenacyl azoles and related azolium derivatives as antifungal agents.
Purification Methods
It crystallises from EtOH/ Et2O or H2O. The hydrochloride has m 151-152o (from EtOH, 1g/10mL). [Allen & Bell Org Synth Coll Vol III 96 1955, Barszez et al. J Chem Soc, Dalton Trans 2025 1986, Beilstein 26 H 16, 26 II 7, 26 III/IV 40, Temple & Montgomery 1,2,4-Triazoles —The Chemistry of Heterocyclic Compounds Vol 37 (Weissberger & Taylor eds.). Wiley & Sons NY 1981, ISBN 0-471-0656-6.]
