티엘라빈A

티엘라빈A
티엘라빈A 구조식 이미지
카스 번호:
71950-66-8
한글명:
티엘라빈A
동의어(한글):
티엘라빈A
상품명:
thielavin A
동의어(영문):
thielavin A;4-[(2,4-Dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester;Benzoic acid, 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethyl-, 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester
CBNumber:
CB61386873
분자식:
C29H30O10
포뮬러 무게:
538.54
MOL 파일:
71950-66-8.mol

티엘라빈A 속성

녹는점
235-236 °C
끓는 점
850.0±65.0 °C(Predicted)
밀도
1.371±0.06 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
DMF: souble; DMSO: souble; Ethanol: soluble
물리적 상태
백색 내지 회백색 분말.
산도 계수 (pKa)
2.82±0.28(Predicted)

안전

티엘라빈A C화학적 특성, 용도, 생산

개요

Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 (PGH2; ) and the conversion of PGH2 to PGE2 (; IC50s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM).

용도

The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.

티엘라빈A 준비 용품 및 원자재

원자재

준비 용품


티엘라빈A 공급 업체

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