15-28-Somatostatin-28
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15-28-Somatostatin-28 속성
- 녹는점
- >211°C (dec.)
- 끓는 점
- 1970.9±65.0 °C(Predicted)
- 밀도
- 1.43±0.1 g/cm3(Predicted)
- 저장 조건
- −20°C
- 용해도
- H2O: 1 mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 2.94±0.70(Predicted)
- 색상
- 흰색에서 황백색까지
- 수용성
- 수용성(25,00°C 1,00 g/L), 메탄올.
- Merck
- 13,8788
- BRN
- 6436064
- 시퀀스
- Ala-Gly-c[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]-OH,(Disulfide bridge: Cys-Cys)
- InChIKey
- NHXLMOGPVYXJNR-ATOGVRKGSA-N
안전
| WGK 독일 | 3 | ||
|---|---|---|---|
| RTECS 번호 | WF8751700 | ||
| F 고인화성물질 | 3-10-21 |
15-28-Somatostatin-28 C화학적 특성, 용도, 생산
화학적 성질
White Powder정의
ChEBI: A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.Biological Functions
Somatostatin is a cyclic 14-peptide that was first isolated by Guillemin in 1973 and is probably the most thoroughly investigated and most important of the inhibitory factors produced by the hypothalamus. The principal activity of somatostatin, which is of hypothalamic origin, is inhibition of the release of growth hormone (GH) from the anterior pituitary. Too much GH, as in pituitary tumors, causes acromegaly, a form of giantism. On the other hand, too little GH leads to dwarfism. Somatostatin also has been found in the pancreas and the GI tract, where it inhibits the secretion of both insulin and glucagon from the pancreas as well as the secretion of a variety of intestinal peptides (e.g., gastrin, secretin, pepsin, and renin). The short half-life of somatostatin, which is less than 3 minutes, has precluded its use as a therapeutic agent. Many derivatives of somatostatin have been prepared to increase its duration of action and/or to enhance its selectivity of action. The culmination of these structure–activity studies was the development of octreotide acetate.일반 설명
Somatostatin (SST) is a peptide.Purification Methods
Somatostatin is a tetradecapeptide which is purified by gel filtration on Sephadex G-25, eluting with 2N AcOH, and then by liquid partition chromatography on Sephadex G-25 using n-BuOH/AcOH/H2O (4:1:5) and has RF = 0.4. It is a brain growth hormone releasing-inhibiting factor which has also been synthesised. [Burgus et al. Proc Natl Acad Sci USA 70 684 1973, Sorantakis & McKinley Biochem Biophys Res Commun 54 234 1973, Hartridt et al. Pharmazie 37 403 1982.]15-28-Somatostatin-28 준비 용품 및 원자재
원자재
L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-L-alanylglycyl-L-cysteinyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-N-(triphenylmethyl)-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-1-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-O-(1,1-dimethylethyl)-L-threonyl-L-phenylalanyl-O-(1,1-dimethylethyl)-L-threonyl-O-(1,1-dimethylethyl)-L-seryl-, [3,4,5-tris(octadecyloxy)phenyl]methyl ester, cyclic (3→14)-disulfide
dihydrosomatostatin
준비 용품
15-28-Somatostatin-28 공급 업체
글로벌( 311)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Cellmano Biotech Limited | 0551-65326643 18156095617 |
info@cellmano.com | China | 999 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11013 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
| Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 |
sales@alphabiopharm.com | China | 886 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15932 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| Rixing Chemical CO.,LTD | +86-13237129059 -13237129059 |
sales@rixingchemi.com | CHINA | 229 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
15-28-Somatostatin-28 관련 검색:
에스에이치-폴리펩타이드-7
SOMATOSTATIN 28, CYCLIC
Somatostatin
Oxytocin
Bivalirudin
H-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH
H-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH
H-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-OH
H-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-OH
SOMATOSTATIN-28 (1-14)
SOMATOSTATIN-28 (1-12)
SOMATOSTATIN-25
SOMATOSTATIN 28
Hexarelin
Growth hormone releasing peptide
15-28-Somatostatin-28
TYR-SOMATOSTATIN-28
AGCKNFFWKTFTSC (DISULFIDE BRIDGE: 3-14), ACETATE SALT