B581
|
|
B581 속성
- 끓는 점
- 716.1±60.0 °C(Predicted)
- 밀도
- 1.161±0.06 g/cm3(Predicted)
- 저장 조건
- −20°C
- 용해도
- H2O: 용해성
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 3.04±0.10(Predicted)
- 색상
- 하얀색
안전
| 안전지침서 | 22-24/25 | ||
|---|---|---|---|
| WGK 독일 | 3 |
B581 C화학적 특성, 용도, 생산
개요
FTase inhibitor I is a potent inhibitor of farnesyltransferase (FTase; IC50 = 21 nM) that is greater than 30-fold selective for FTase over geranylgeranyl transferase (GGTase; IC50 = 790 nM). It prevents farnesylation of Ras and inhibits proliferation of cells transformed by Ras farnesylation. In a dog model of subarachnoid hemorrhage, it reduces GTP-Ras in spastic basilar arteries, decreases angiographic vasospasm, and improves clinical scores.용도
FTase Inhibitor I is a potent, selective, peptidomimetic FTase inhibitor.정의
ChEBI: A dipeptide obtained from the tetrapeptide Cys-Val-Phe-Met by reduction of the amide carbonyl groups of the Cys and Val residues.효소 저해제
This cell-permeable CAAX peptidomimetic (FW = 470.70 g/mol; FWtrifluoracetate-salt = 583.71 g/mol; CAS 149759-96-6), named as N-[2(S)- (2(R)-2-amino-3-mercaptopropylamino)-3-methylbutyl]-L-phenylalanyl-L methionine), binds to and prevents protein farnesyltransferase (IC50 = 21 nM) from interacting with C-terminal L-Cys-L-Val-L-Phe-L-Met substrate recognition sequences that are present in its natural substrates. Otherwise hydrophilic proteins associate with membranes by means of enzymatic attachment of hydrophobic moieties to their C-termini. Whereas prenylation occurs in the cytosol, post-prenylation processing is accomplished on the cytoplasmic surface of the endoplasmic reticulum and Golgi apparatus. B581 inhibits prenylation and processing of H-ras and lamin A. B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation.B581 준비 용품 및 원자재
원자재
준비 용품
B581 공급 업체
글로벌( 76)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 |
sales@alphabiopharm.com | China | 886 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29016 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 |
sales@nextpeptide.com | China | 19915 | 58 |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 |
support@tgpeptide.com | China | 3279 | 58 |
| Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| Alabiochem Tech.Co., Ltd. | 0512-58900862 400-0707518 |
sales@alabiochem.com | China | 995 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696; |
info@hanhongsci.com | China | 42982 | 64 |