Agmatine sulfate
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Agmatine sulfate 속성
- 녹는점
- 234-238 °C(lit.)
- RTECS 번호
- ME8413000
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- H2O: 50 mg/mL
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 물에 용해되고 알코올에는 거의 녹지 않음
- Merck
- 14,188
- BRN
- 3918807
- InChI
- InChI=1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
- InChIKey
- PTAYFGHRDOMJGC-UHFFFAOYSA-N
- SMILES
- C(CCCN)NC(N)=N.S(O)(O)(=O)=O
- CAS 데이터베이스
- 2482-00-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
Agmatine sulfate C화학적 특성, 용도, 생산
개요
Agmatine sulfate is the sulfate of the Agmatine. Agmatine is an aninoguanidine that is naturally derived from the arginine. It can exert modulatory effect on many molecular targets such as neurotransmitter systems, opioid analgesia, ion channels, and nitric oxide (NO) synthesis and polyamine metabolism. It has been also found that it can reverse the pain induced from inflammation, neuropathy, and spinal cord injury. Those effects make it a potential candidate for multiple pharmacological applications in the future.화학적 성질
White to off-white powder용도
Agmatine Sulfate is a a polyamine derived from L-arginine (A769500) decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine a t α2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects.생물학적 활성
Arginine metabolite that is synthesized within bovine brain and exhibits clonidine-displacing substance (CDS) activity. Putative endogenous ligand for the imidazoline binding site.Purification Methods
Crystallise the salt from aqueous MeOH. The free base has m 101.5-103o, the gold chloride hydrochloride crystallises from H2O with m 223o(dec), and the picrate has m 236-238o. [Odo J Chem Soc Jpn 67 132 1946, Beilstein 4 I 420, 4 II 703, 4 III 575, 4 IV 1291.]참고 문헌
Fairbanks, C. A., et al. "Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury." Proceedings of the National Academy of Sciences of the United States of America97.19(2000):10584.Kolesnikov, Yuri, S. Jain, and G. W. Pasternak. "Modulation of opioid analgesia by agmatine." European Journal of Pharmacology296.1(1996):17-22.
Su, R. B., J. Li, and B. Y. Qin. "A biphasic opioid function modulator: agmatine. "Acta Pharmacologica Sinica24.7(2003):631.
Galea, Elena, et al. "Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine." Biochemical Journal 316 ( Pt 1).1(1996):247.
https://en.wikipedia.org/wiki/Agmatine
Agmatine sulfate 준비 용품 및 원자재
원자재
준비 용품
Agmatine sulfate 공급 업체
글로벌( 479)공급 업체
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