나린진

나린진 속성

나린진 MSDS

7-(2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyloxy)-2,3-dihydro-4',5,7-trihydroxyflavone

나린진 C화학적 특성, 용도, 생산

순도시험

  (1) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.

  (2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 5.0ppm 이하이어야 한다.

  (3) 잔류용매 : 이 품목을 「파프리카추출색소」의 순도시험 (5)에 따라 시험할 때, 메탄올 50ppm 이하이어야 한다.

확인시험

  (1) 이 품목 5mg에 50% 에탄올 10mL를 가하여 녹이고 염화제이철용액(1→500)을 1∼2방울을 가하였을 때 그 액은 갈색을 나타낸다.

  (2) 이 품목 5mg에 수산화나트륨시액 5mL를 가하고 용해시켰을 때 그 액은 등황∼황색을 나타낸다.

  (3) 이 품목 10mg에 물 500mL를 가하여 녹인 액은 파장 280∼285nm에서 극대흡수부가 있다.

정량법

  이 품목을 105℃에 3시간 건조시킨 후 약 0.2g을 정밀히 달아 50% 에탄올에 녹인 후 정확히 100mL로 한다. 이 액을 0.45㎛ 필터에 여과시킨 후, 이 액 1mL을 정확히 취하여 물을 가하여 100mL로 한 것을 시험용액으로 사용한다. 물을 대조액으로 하여 280nm에서의 흡광도를 측정하여 다음 계산식에 따라 함량을 계산한다.

                    A : 시험용액의 흡광도

정의

  이 품목은 운향과 귤(Citrus paradisi MACF.) 등의 과피, 과즙 또는 종자를 물 또는 상온의 에탄올 또는 메탄올로 추출하고 분리 정제하여 얻어지는 것으로서 그 성분은 나린진이다.

개요

Naringin is also called naringoside, hesperidin, and isohesperidin. It is a pale yellow flavanone compound extracted from immature or nearly mature outer layer of C. paradisi Macfad which belongs to Citrus grandis (L.) Osbeck. It tastes bitter and is naturally existed in the skin and flesh of Rutaceae like grapefruit, mandarin orange, and orange. It is also one of the active ingredients in many traditional Chinese medi cines like Rhizoma Drynariae, Immature Bitter Orange, Fructus Aurantii, and Exocarpium Citri Grandis. The contents of naringin in different plants vary greatly with the category and origin, and the content of naringin is high in immature fruits . In terms of traditional Chinese medicine, the flavor of grapefruit is sweet and sour, and the nature is cold; the flavors of its peel are sweet, pungent, and bitter, and the nature of its peel is warm. Both the pulp and the peel of grapefruit have the bio logical function including reducing phlegm, helping digestion, relieving abdominal distention, and fast diaphragm. And they are mainly used for the treatment of cough with asthma, sense of suppression in the chest, coldness and pain in abdomen, dys peptic retention, and hernia.

화학적 성질

beige to yellowish powder

물리적 성질

Appearance: white to light yellow crystalline powder. Solubility: soluble in metha nol, ethanol, acetone, acetic acid, dilute alkali solution, and hot water and insoluble in nonpolar solvent like petroleum benzin, ether, benzene, and chloroform. Melting

역사

Naringin is mainly existed in the peel of grapefruit, lime, and their varieties; it has multiple biological activities and is widely applied in the fields of medicine, food, and cosmetics. In the 1930s, Harvey and Rygg obtained naringin through the method of isolation and extraction. They also established a colorimetric method for the determination of naringin, which laid the foundation for the following researches . Booth and other researchers conducted the systematic researches on the narin gin metabolites . In the 1960s, Hagen and other researchers established a fluores cence chromatography method for the determination naringin . In addition, the biological activity of naringin was evaluated. It was observed to improve ascites, experimental pulmonary edema, peritonitis, and oxygenation . At present, the extraction methods of naringin are hot water extraction, alkali extraction, and acid precipitation and organic solvent extraction. A series of pharmacological activity studies have been conducted and demonstrated its various biological activities .

용도

Naringoside is a metabolite of Naringin (N378980), a major flavonoid found in grapefruit juice. It has antioxidant, lipid lowering, and anticancer activities. It is also an inhibitor of cytochrome P450 enzymes, affecting drug metabolism and thus drug absorption in humans.

정의

ChEBI: A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosi ic linkage.

일반 설명

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Clinical Use

It was used for the treatment of bacterial infection, calm, and cancer prevention

Purification Methods

This bitter principle from grape juice crystallises from water to give the hydrate with 6-8 H2O which when dried at 110o gives the dihydrate. Its solubility in H2O is 0.1% at 40o and 10% at 75o. The 2,4-dinitrophenylhydrazone crystallises from aqueous dioxane with m 246-247o [Douglass et al. J Am Chem Soc 73 4023 1951]. [Pulley & von Loesecke J Am Chem Soc 61 175 1939, Beilstein 18 III/IV 2637, 18 V 528.]

나린진 준비 용품 및 원자재

원자재

준비 용품

나린진 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Jiurui Biology Chemistry Co.,Ltd.	+86-0744-8561603 +8619974416182	sales11@jiuruibiochem.com	China	26	58
Changsha Staherb Natural Ingredients Co., Ltd.	+86-0731-84213302 +8618374838656	sales@staherb.cn	China	1025	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+8618829768577	gao490372054@gamil.com	China	1250	58
Hebei Kingfiner Technology Development Co.Ltd	+86-0086-031185030958 +8615532196582	lisa@kingfinertech.com	China	2987	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	958	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	326	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	2991	58

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