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5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 구조식 이미지

카스 번호:: 3543-74-6

상품명:: 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

동의어(영문):: Bendamustine USP RC C;Bendamustine Impurity 40;Bendamustine Dihydroxy Ester;Bendamustine Related Impurity 1;Bendamustine Related Compound C;Bendamustine USP Related Compound C;5-[Bis(2-hydroxyethyl)amino]-1-meth;ethyl 4-(5-(bis(2-hydroxyethyl)amino);Bendamustine hydrochloride Intermediates 1;Bendamustine USP RC C /Bendamustine Impurity A

CBNumber:: CB92485093

분자식:: C18H27N3O4

포뮬러 무게:: 349.42

MOL 파일:: 3543-74-6.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 183

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 속성

녹는점: 98-101°C

끓는 점: 580.6±50.0 °C(Predicted)

밀도: 1.21±0.1 g/cm3(Predicted)

저장 조건: Sealed in dry,Store in freezer, under -20°C

용해도: 클로로포름(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 14.26±0.10(Predicted)

색상: 흰색에서 갈색으로

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

HS 번호	2933998350

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H301	삼키면 유독함	급성 독성 물질 - 경구	구분 3	위험	P264, P270, P301+P310, P321, P330,P405, P501
H341	유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)	생식세포 변이원성 물질	구분 2	경고	P201,P202, P281, P308+P313, P405,P501
H351	암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재)	발암성 물질	구분 2	경고	P201, P202, P281, P308+P313, P405,P501

예방조치문구:

P201	사용 전 취급 설명서를 확보하시오.
P202	모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P310	삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester C화학적 특성, 용도, 생산

화학적 성질

Off-White to Light Tan Solid

용도

[1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester_x000D_Bendamustine Related Impurity 1 (cas# 3543-74-6) is a compound useful in organic synthesis.

Synthesis

Stir and dissolve 5-amino-1-methyl-1H-2-benzimidazole butyric acid ethyl ester (60g, 0.23mol), 600mL water, and 300mL glacial acetic acid in a 2L reaction flask, and cool to -50, Add 120 mL of ethylene oxide, and control the temperature to complete the reaction. Adjust the pH of the potassium carbonate solution to 7.0-7.3, extract with dichloromethane 300 mL×3, combine the organic phases, wash with purified water 200 mL×3, dry with anhydrous magnesium sulfate, filter, and concentrate to obtain a brown solid. Then add 1200 mL of ethyl acetate and heat to 70-80° C. to dissolve, cool to room temperature to crystallize, filter and dry to obtain 63 g of light brown solid 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester with a purity of 99.3%. The yield was 78.5%.

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 준비 용품 및 원자재

원자재

2,2'-((4-(메틸아미노)-3-나이트로페닐)이미노)디에탄올 1H-Benzimidazole-2-butanoic acid, 5-[bis(2-hydroxyethyl)amino]-2,3-dihydro-2-hydroxy-1-methyl- oxirene 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid Pentanoic acid, 5-[(2-fluoro-5-nitrophenyl)amino]-5-oxo- 2-Fluoro-5-nitroaniline 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 1-Methyl-5-nitro-2-benzimidazolebutyric acid 2,2'-[(4-fluoro-3-nitrophenyl)imino]bisethanol 1-Methyl-5-nitro-1H-benzimidazole-2-butanoic Acid Ethyl Ester 에틸렌옥사이드 2-브로모에탄올 에틸알코올

준비 용품

Bendamustine hydrochloride

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 공급 업체

글로벌( 183)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	16799	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15965	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9342	55
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	925	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 관련 검색:

Bendamustine Impurity 26 FMOC-GLY-GLY-GLY-OH BEPOTASTINE BESILATE 5-alpha-Hydroxy- Laxogenin 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate Bendamustine Desmethyl Impurity Bendamustine Ether Impurity Bendamustine Impurity 28 DesMethyl BendaMustine Hydrochloride BendaMustine IMpurity B 5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Bendamustine Impurity 8 Bendamustine Impurity D 5-[bis-(2-Chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Bendamustine Impurity 14 BendaMustine IMpurity C　　 5-[(2-Chloroethyl)(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid