Pyridoxamine dihydrochloride

Pyridoxamine dihydrochloride 속성

Pyridoxamine dihydrochloride MSDS

Pyridoxamine dihydrochloride

Pyridoxamine dihydrochloride C화학적 특성, 용도, 생산

개요

Pyridoxamine dihydrochloride is a salt and amine form of pyridoxamine, which belongs to the family of vitamin B6 compounds. Pyridoxamine occurs naturally in animal-based food products. Its deficiency in humans potentially causes sideroblastic anemia, weakness, insomnia, and neurological disorders. It has been reported to be effective against diabetic nephropathy. Pyridoxamine dihydrochloride acts as a catalyst in the metabolism of fats, carbohydrates, and proteins in the body, thereby assisting in maintaining energy balance in kidney disease patients.

화학적 성질

It is a white to yellowish crystal or crystalline powder that readily absorbs moisture. It is generally stable at room temperature but tends to change color when exposed to light. Its melting point is at 226-227℃, with decomposition. It exhibits maximum absorption at a wavelength of 287.5nm. The substance is soluble in water, slightly soluble in ethanol, but insoluble in ether or chloroform.

용도

Pyridoxamine dihydrochloride (Pyridorin, NephroGenex, 524-36-7) inhibits formation of advanced glycation end products and scavenges reactive oxygen species and toxic carbonyls. Whether these effects translate into kidney protection is unknown, although a year-long study of the effects of pyridoxamine dihydrochlo-ride in patients with type 2 diabetes and proteinuria failed to show a difference in kidney function decline with pyri-doxamine dihydrochloride in daily doses of 300 or 600 mg versus placebo treatment.

제조 방법

The procedure for preparing pyridoxamine dihydrochloride involves several steps: firstly enabling pyridoxal oxime to react with acetic acid and zinc to obtain acetic acid solution containing pyridoxamine, then decompressing the solution and reclaiming the acetic acid to obtain slurry concentrate, decompressing and reclaiming the acetic acid again to obtain pyridoxamine water solution, regulating the pH value to be alkaline so as to separate pyridoxamine out, adding water and hydrochloric acid after vacuum filteration, decoloring and filtering to obtain filtrate, decompressing and concentrating the filtrate until white solids are separated out, adding solvent and stirring, and finally crystallizing at the lower temperature, filtering and drying to obtain the pyridoxamine dihydrochloride.
CN101628892A

정의

ChEBI: Pyridoxamine dihydrochloride is a hydrochloride obtained by combining pyridoxamine with two molar equivalents of hydrochloric acid. Used for treatment of diabetic nephropathy. It has a role as an Escherichia coli metabolite, a Saccharomyces cerevisiae metabolite, a human metabolite, a mouse metabolite, a plant metabolite, an iron chelator and a nephroprotective agent. It is a hydrochloride and a vitamin B6. It contains a pyridoxamine(2+).

Pharmacokinetics

The progression of diabetic nephropathy can be blocked by Pyridoxamine dihydrochloride, a derivative of vitamin B6, which is a potent inhibitor of AGE formation. However, it has been observed that this treatment is only effective in patients who have relatively preserved kidney function (baseline SCr 1.3 to 1.9 mg/dL).

Purification Methods

The amine salt is crystallised from hot MeOH. The free base crystallises from EtOH with m 193-193.5o [Harris et al. J Biol Chem 154 315 1944, J Am Chem Soc 66 2088 1944]. [Beilstein 22 IV 6064, 22/12 V 324.]

Pyridoxamine dihydrochloride 준비 용품 및 원자재

원자재

준비 용품

Pyridoxamine dihydrochloride 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	2991	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Cangzhou Wanyou New Material Technology Co.,Ltd	18631714998	sales@czwytech.com	CHINA	906	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58

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