BEKM-1

BEKM-1 C화학적 특성, 용도, 생산

효소 저해제

This ERG channel inhibitor (FW = 4091.65 g/mol; CAS 524962-01-4; Soluble to 1 mg/mL in H2O), from the Central Asian scorpion Buthus eupeus, targets human KV11.1 Ether-a-go-go-Related Gene potassium ion currents. BeKm-1 inhibits hERG1 channels (IC50 = 3.3 nM), but has little or no effect, even at 100 nM, on hEAG, hSK1, rSK2, hIK, hBK, KCNQ1/KCNE1, KCNQ2/3, and KCNQ4 channels. BeKm-1 shares a molecular scaffold (consisting of a short a-helix and a triple-stranded antiparallel b-sheet) in common with other short scorpion toxins. Site- directed mutagenesis identified Tyr-11, Lys-18, Arg-20, and Lys-23 as key residues for binding to hERG channels. All four are located in the a-helix and its following loop, whereas the canonical functional site of other short scorpion toxins lies within the b-sheet. BeKm-1 significantly prolongs QTc intervals in isolated rabbit hearts (4.7 at 10 nM, 16.3% at 100 nM), concentrations that inhibit hERG1 channels.

BEKM-1 준비 용품 및 원자재

원자재

준비 용품

BEKM-1 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Beijing Sizhengbai Biotechnology Co., Ltd.	--	marketing@4abio.com	CHINA	6401	58
Beijing Qunxiao Keyuan Biotechnology Co., Ltd.	--	mail@qbioscience.com	CHINA	21	58
Beijing Bai Ao Si Biotechnology Co., Ltd.	--	yangmei@bioneeds.net	CHINA	6999	58
Beijing Bolide Biotechnology Co., Ltd.	--	1985563437@qq.com	CHINA	6172	58
Riedel-de Haen AG	--		United States	6825	87
SIGMA-RBI	--		Switzerland	6913	91
EMD Biosciences, Inc.	--	technical@calbiochem.com	United States	6529	66