Terbinafine Hydrochloride
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Terbinafine Hydrochloride 속성
- 녹는점
- 204-208°C
- 저장 조건
- 15-25°C
- 용해도
- 메탄올: 용해성50mg/mL
- 물리적 상태
- 가루
- 색상
- 하얀색
- Merck
- 14,9156
- BCS Class
- 1
- InChI
- InChI=1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;
- InChIKey
- BWMISRWJRUSYEX-SZKNIZGXSA-N
- SMILES
- C12C=CC=CC1=CC=CC=2CN(C)C/C=C/C#CC(C)(C)C.Cl
- CAS 데이터베이스
- 78628-80-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,N | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38-50/53 | ||
| 안전지침서 | 26-36/37/39-61-60 | ||
| 유엔번호(UN No.) | UN 3077 9/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | QJ8600100 | ||
| HS 번호 | 29214990 | ||
| 독성 | LD50 in mice, rats (mg/kg): 4000, 4000 orally; 393, 213 i.v. (Ganzinger) |
Terbinafine Hydrochloride C화학적 특성, 용도, 생산
개요
Terbinafine hydrochloride is the first orally active allylamine antifungal with 30-fold greater antifungal activity than naftifine. The compound is indicated for the treatment of ringworm and fungal nail infections. Terbinatine hydrochloride acts on a single fungal enzyme, squalene epoxidase, interfering with the biosynthesis of ergosterols in cell membranes. Unlike other antifungal agents, it does not inhibit cytochrome P450 enzymes.화학적 성질
Terbinafine hydrochloride is an off-white crystalline material that is soluble in polar organic solventssuch as methanol, ethanol, and methylene chloride but isonly slightly soluble in water. The highly lipophilic freebase is insoluble in water.정의
ChEBI: A hydrochloride obtained by reaction of terbinafine with one molar equivalent of hydrogen chloride.Indications
Terbinafine Hydrochloride is a synthetic allylamine antifungal agent, structurally related to naftifine. It inhibits fungal sterol biosynthesis by inhibiting the enzyme squalene 2,3-epoxidase. The deficiency of ergosterol and concomitant accumulation of squalene within the fungal cell results in cell death. It can be fungicidal or fungistatic, depending on the concentration used, and is effective against dermatophytes, Aspergillus, blastomycosis, and histoplasmosis. It is only minimally effective against Candida.일반 설명
Terbinafine Hydrochloride is a synthetic allylamine derivative structurally related to naftifine, antifungal Terbinafine Hydrochloride blocks ergosterol biosynthesis by inhibition of squalene epoxidase, part of the sterol synthesis pathway for the fungal cell membrane.생물학적 활성
Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. metagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml). It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively). Terbinafine (90-120 μM) induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and human umbilical vein endothelial cells (HUVECs). Formulations containing terbinafine have been used in the treatment of nail and skin fungal infections.Biochem/physiol Actions
Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.
부작용
Adverse reactions include lens and retinal disturbances (red/green visual perception), metallic taste disturbance that may last up to 4 weeks after medication discontinuation, hepatoxicity, and pancytopenia. Five percent of patients will experience delayed gastric emptying with symptoms of nausea, fullness, and/or dyspepsia. Terbinafine does not appear to have any effect on the cytochrome P-450 systems (Check baseline CBC and LFTs; repeat if taken for >6 weeks).Synthesis
Terbinafine is produced from olefin metathesis of 1,3-dichloropropene and neohexene followed by reaction with N-methyl-1-naphthalenemethanamine.Terbinafine Hydrochloride 준비 용품 및 원자재
원자재
N-메틸-1-나프탈렌메틸아민 수화염화물
N-Methyl-1-naphthalenemethanamine
1,3-디클로로프로펜
3.3-디메틸-1-부텐
(2E)-N,6,6-trimethyl-2-Hepten-4-yn-1-amine
탄산나트륨(경회)
디클로로메탄
준비 용품
Terbinafine Hydrochloride 공급 업체
글로벌( 929)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 |
sales@sdperfect.com | China | 294 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 |
info@pharmachemm.com | China | 222 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 |
1012@dideu.com | China | 3371 | 58 |
| Xi'an ZB Biotech Co.,Ltd | +8618591943808 |
sales01@xazbbio.com | China | 816 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9339 | 58 |
| Chengdu Aupone Pharmaceutical Co.Ltd. | +86-28-+86-28-87843998-6060-6060 +8618631098571 |
lijiaqi@aupone.com | China | 43 | 58 |
| Shanghai Jinhuan Chemical CO.,LTD. | +86-21-52210535 +8613162045318 |
sales@jinhchem.com | China | 332 | 58 |
| SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. | +86-0531-69954981 +8615666777973 |
dwyane.wang@boyuanpharm.com | China | 211 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 959 | 58 |
Terbinafine Hydrochloride 관련 검색:
N,N-다이메틸폼아마이드 3,3-디메틸-1-부틴 N-메틸-1-나프탈렌메틸아민 수화염화물 다이메틸 설폭사이드 디메틸 에테르 다이메틸 프탈레이트 에탄 메틸아민 하이드로클로라이드 황화디메틸 다이메틸 푸마르산 트라이메틸아민(트리메틸아민) 테르비나핀 메틸아민
Flunixin meglumine
1-Chloro-6,6-dimethyl-2-heptene-4-yne
Topotecan hydrochloride
Meglumine
N-[(2E)-6,6-DiMethyl-2-hepten-4-yn-1-yl]-N,4-diMethyl-1-naphthaleneMethanaMine Hydrochloride