Mecarbam is a pale yellow to light brown oil, bp
144 ?C/0.02 mm Hg. It is slightly soluble in water (<0.1%
at 25 ?C) and miscible with most organic solvents except
alkanes. Log Kow = 2.6. It is readily hydrolyzed in aqueous
media below pH 3.
화학적 성질
Yellow oil.
용도
Mecarbam is an organothiophosphate acaricides used to control powdery mildew of cucumbers.
정의
ChEBI: An organic thiophosphate that is O,O-diethyl hydrogen phosphorodithioate in which the hydrogen attached to a sulfur is replaced by a 2-[(ethoxycarbonyl)(methyl)amino]-2-oxoethyl group.
위험도
Highly toxic, cholinesterase inhibitor. Use
may be restricted.
신진 대사 경로
Mecarbam in a close chemical analogue of dimethoate and it is photolytically
decarboxyethylated to the diethyl analogue of dimethoate. The main
route of hydrolytic decomposition in moderately basic solution is via
attack on the S-methylene carbon atom rather than on phosphorus or the
carbamoyl group, followed by cleavage of the S-C bond yielding O,Odiethyl
phosphorodithioate as the main product. Mecarbam oxon has
been reported as a metabolite in plants and animals but few detailed
studies have been reported on the metabolic or environmental fate of
mecarbam.
신진 대사
In mammals, mecarbam
is rapidly metabolized by hydrolysis, oxidative desulfuration
to the oxon, and degradation of the carbamoyl moiety.
O-Deethylation also takes place to a minor extent. In soil,
it persists for 4–6 weeks.
