Trimetazidine dihydrochloride manufacturers and suppliers

Trimetazidine dihydrochloride suppliers

Properties

Melting point:: 231-235 °C(lit.)

storage temp.: Refrigerator

solubility: Freely soluble in water, sparingly soluble in alcohol.

color: White to Off-White

Merck: 14,9705

Stability:: Hygroscopic

InChIKey: XIRALXKCBGTYSC-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes: Xn,Xi

Risk Statements: 22-36/37/38

Safety Statements: 26-36

WGK Germany: 3

RTECS: TM2976100

HazardClass: IRRITANT

HS Code: 29339900

Toxicity: LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey)

Use

Trimetazidine dihydrochloride is the dihydrochloride salt of Trimetazidine. It is a drug used for the treatment of angina pectoris. It is capable of improving the left ventricular function in diabetic patients suffering coronary heart disease as well as treating the symptoms of patients suffering heart failure of different etiologies. It takes effects through acting as an anti- ischemic metabolic agent being capable of improving the utilization efficiency of myocardial glucose by inhibiting the metabolism of fatty acid (through inhibiting the activity of mitochondrial long- chain 3-ketoacyl coenzyme A Thiolase). The shift from fatty acid oxidation to glucose oxidation optimizes cellular energy process in cells exposed to hypoxia or ischaemia, further maintaining the intracellular ATP levels and ensuring the normal function of ionic pumps and transmembrane sodium-potassium flow to maintain cellular homeostasis.

You can find Trimetazidine dihydrochloride suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.