Cenicriviroc suppliers
Cenicriviroc
- CAS:
- 497223-25-3
- MF:
- C41H52N4O4S
- MW:
- 696.94
Suppliers by country/region
Company Type
Properties
- Boiling point:
- 913.5±65.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 5 mg/ml
- form
- A crystalline solid
- pka
- 12.96±0.70(Predicted)
Safety Information
Use
Cenicriviroc is a dual antagonist of chemokine receptor types 2 and 5 (CCR2/CCR5). The receptors are found on Kupffer cells and hepatic stellate cells, and preclinical studies suggest its anti-inflammatory and anti-fibrotic activity. In the phase 2b CENTAUR study, cenicriviroc treatment for 1 year failed to achieve the primary outcome of a decrease in NAFLD activity score by ≥2 points with no worsening of fibrosis. Nonetheless, one of the key secondary outcomes, improvement in liver fibrosis without worsening of NASH, was achieved in 20% in the treatment group, compared with 10% in the placebo group. Besides, cenicriviroc reduced the serum levels interleukin- 6, C-reactive protein and fibrinogen, suggesting its action on inflammation that may not be reflected by crude histological assessment. A phase 3 study is planned.
65 supplier list of "Cenicriviroc"
- Product Name:Cenicriviroc;TAK652
- Products Intro:Purity: 98% | Package: 5MG;10MG;50MG;100MG,1G,5G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:Cenicriviroc
- Products Intro:Purity: >=98% | Package: 50mg | CustNote: BOC Sciences also provides custom synthesis services for Cenicriviroc.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:Cenicriviroc
- Products Intro:Purity: 0.99summer | Package: 5KG;1KG | CustNote: Summer 618
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Cenicriviroc
- Products Intro:CustNote: https://www.alfa-chemistry.com/cenicriviroc-cas-497223-25-3-item-292203.htm
- Company Type: Reagent
- Country/Region: UNITED STATES
- Main Products: Active Pharmaceutical Ingredient (API),Insect Pheromone,Boronic Compounds,Material & Chemicals,Lipid Compounds
- Product Name:Cenicriviroc
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Fine Chemical,API,Raw Material,Pharmaceutical Compounds,Others
- Product Name:Cenicriviroc
- Products Intro:Purity: 0 | Package: 1g; 5g; 25g; 1kg; 5kg; 25kg | CustNote: 0
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical intermediate
- Product Name:Cenicriviroc
- Products Intro:Purity: 95%+ | Package: 5g;10g;1kg;10kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Creatine monohydrate,BENZYL L-LACTATE,Quinoline-5-carboxylic acid,6-AMINOINDANONE,Methyl 2-AMino-1H-benzoiMidazole-4-carboxylate
- Product Name:cenicriviroc
- Products Intro:Purity: 97% | Package: $41.9/1mg;$173.9/5mg;$565.9/25mg;$1708.9/100mg;Bulk package | CustNote: 97%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
- Product Name:cenicriviroc
- Products Intro:Purity: 0.98 | Package: 100KG;25KG;10KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Cenicriviroc
- Products Intro:Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A858124
- Company Type: Reagent
- Country/Region: CHINA