Mirin manufacturers and suppliers

Mirin suppliers

Mirin

CAS:: 299953-00-7

MF:: C10H8N2O2S

MW:: 220.25

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Properties

Melting point:: 295-297 °C(Solv: ethanol (64-17-5))

Boiling point:: 441.6±55.0 °C(Predicted)

Density: 1.49±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO: >10mg/mL

form: Reddish orange powder

pka: 9.15±0.30(Predicted)

color: red to orange

Sensitive: Moisture Sensitive

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes: Xi

Risk Statements: 36

Safety Statements: 26

WGK Germany: 3

Use

The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during DNA replication, and activates and recruits ataxia-telangiectasia mutated (ATM) to damaged DNA. The genes that encode the MRN proteins are all essential for cell viability, so functional studies of MRN cannot involve deletion of these genes. Mirin is an inhibitor of MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 μM). Through its effects on MRN, mirin prevents activation of ATM. Inhibition of MRN centers on the ability of mirin to block the nuclease activity of Mre11, rather than altering DNA-binding or MRN complex formation. In cells, mirin induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed repair of DNA damage.[Cayman Chemical]

You can find Mirin suppliers, manufacturers, and distributors from countries such as China, United States and the Canada here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.