MonoMethyl auristatin E manufacturers and suppliers

MonoMethyl auristatin E suppliers

MonoMethyl auristatin E

CAS:: 474645-27-7

MF:: C39H67N5O7

MW:: 717.98

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Properties

Melting point:: >90°C (dec.)

Boiling point:: 873.5±65.0 °C(Predicted)

Density: 1.088±0.06 g/cm3(Predicted)

storage temp.: -20°C Freezer

solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)

pka: 13.66±0.20(Predicted)

form: Solid

color: White to Off-White

InChIKey: RJACXSRFJLSJEZ-UIJRFTGLSA-N

SMILES: C(NC(=O)[C@H](C(C)C)NC)(=O)[C@H](C(C)C)N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1CCC[C@H]1[C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)=O)=O)C

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P305+P351+P338

Use

Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization. Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity. MMAE is typically coupled to the antibody via a protease-cleavable linker, allowing separation of the drug from the antibody following intracellular localization.[Cayman Chemical]

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