Nimesulide manufacturers and suppliers

Nimesulide suppliers

Properties

Melting point:: 140-146°C

Boiling point:: 442.0±55.0 °C(Predicted)

Density: 1.451±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.

pka: pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)

color: Light orange to Yellow to Green

Water Solubility: Soluble in water (<50 µg/ml), 1:10 DMSO:PBS (pH 7.2) (<200 µg/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.

λmax: 391nm(H2O)(lit.)

Merck: 14,6548

Stability:: Stable. Incompatible with strong oxidizing agents.

InChIKey: HYWYRSMBCFDLJT-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P301+P310+P330

Hazard Codes: Xn,Xi

Risk Statements: 22-36/37/38

Safety Statements: 36-26

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: PB0970000

HS Code: 2935.90.9500

HazardClass: 6.1

PackingGroup: III

Toxicity: LD50 orally in rats: 324 mg/kg (Swingle, Moore)

Use

Labelled Nimesulide . Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.;Labeled Nimesulide, intended for use as an internal standard for th

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