Panitumumab manufacturers and suppliers

Panitumumab suppliers

Panitumumab

CAS:: 339177-26-3

MF:

MW:: 0

Suppliers by country/region

Company Type

Properties

storage temp.: Store at -20°C

Safety Information

Use

Panitumumab is a recombinant, fully human IgG2 kappa monoclonal antibody that is highly selective for the epidermal growth factor receptor (EGFR), and it is indicated for the treatment of EGFR-expressing, metastatic colorectal carcinoma (mCRC) with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Overexpression of EGFR is detected in many human cancers, including those of the colon and rectum. Panitumumab blocks the binding of ligands such as epidermal growth factor (EGF) and transforming growth factor (TGF-a) to various EGFR-expressing cell lines, which results in inhibition of EGF-dependent tumor cell activation, induction of apoptosis, and decreased pro-inflammatory cytokine and vascular growth factor production. In vitro, panitumumab binds EGFR with high affinity (KD ? 50pM; IC50 ? 3 nM) in human cervical epidermal cell line A-431. .

You can find Panitumumab suppliers, manufacturers, and distributors from countries such as China, United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.