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ChemicalBook >> CAS DataBase List >> 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid

1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid

1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid price.
  • $62 - $1800
  • Product name: 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid
  • CAS: 1193383-09-3
  • MF: C12H6ClF3N4O3
  • MW: 346.65
  • EINECS:
  • MDL Number:MFCD25541711
  • Synonyms:1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid;JNJ-42041935;1-[6-Chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-1H-pyrazole-4-carboxylic acid;HIF-PHD Inhibitor II;CS-1577;JNJ 42041935;JNJ42041935;HIF-PHD INHIBITOR II;1-(5-Chloro-6-(trifluoromethoxy)-1H-benzo[d]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 1-[6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-
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  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number7743DF
  • Product descriptionJnj-42041935
  • Packaging10mg
  • Price$364
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4752
  • Product descriptionJNJ-42041935
  • Packaging1mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4752
  • Product descriptionJNJ-42041935
  • Packaging5mg
  • Price$171
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4752
  • Product descriptionJNJ-42041935
  • Packaging10mg
  • Price$272
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14316
  • Product descriptionJNJ-42041935 ≥98%
  • Packaging1mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14316
  • Product descriptionJNJ-42041935 ≥98%
  • Packaging5mg
  • Price$151
  • Updated2024-03-01
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  • ManufacturerCayman Chemical
  • Product number14316
  • Product descriptionJNJ-42041935 ≥98%
  • Packaging10mg
  • Price$239
  • Updated2024-03-01
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  • ManufacturerChemScene
  • Product numberCS-4216
  • Product descriptionJNJ-42041935 99.79%
  • Packaging5mg
  • Price$144
  • Updated2021-12-16
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  • ManufacturerChemScene
  • Product numberCS-4216
  • Product descriptionJNJ-42041935 99.79%
  • Packaging10mg
  • Price$228
  • Updated2021-12-16
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  • ManufacturerCrysdot
  • Product numberCD31004351
  • Product descriptionJNJ-42041935 98+%
  • Packaging10mg
  • Price$191
  • Updated2021-12-16
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  • ManufacturerDC Chemicals
  • Product numberDC8617
  • Product descriptionJNJ-42041935 >98%
  • Packaging100mg
  • Price$500
  • Updated2021-12-16
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  • ManufacturerDC Chemicals
  • Product numberDC8617
  • Product descriptionJNJ-42041935 >98%
  • Packaging250mg
  • Price$900
  • Updated2021-12-16
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  • ManufacturerDC Chemicals
  • Product numberDC8617
  • Product descriptionJNJ-42041935 >98%
  • Packaging1g
  • Price$1800
  • Updated2021-12-16
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  • ManufacturerTRC
  • Product numberJ211318
  • Product descriptionJNJ42041935
  • Packaging25mg
  • Price$480
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 7743DF Jnj-42041935 10mg $364 2021-12-16 Buy
ApexBio Technology C4752 JNJ-42041935 1mg $68 2021-12-16 Buy
ApexBio Technology C4752 JNJ-42041935 5mg $171 2021-12-16 Buy
ApexBio Technology C4752 JNJ-42041935 10mg $272 2021-12-16 Buy
Cayman Chemical 14316 JNJ-42041935 ≥98% 1mg $62 2024-03-01 Buy
Cayman Chemical 14316 JNJ-42041935 ≥98% 5mg $151 2024-03-01 Buy
Cayman Chemical 14316 JNJ-42041935 ≥98% 10mg $239 2024-03-01 Buy
ChemScene CS-4216 JNJ-42041935 99.79% 5mg $144 2021-12-16 Buy
ChemScene CS-4216 JNJ-42041935 99.79% 10mg $228 2021-12-16 Buy
Crysdot CD31004351 JNJ-42041935 98+% 10mg $191 2021-12-16 Buy
DC Chemicals DC8617 JNJ-42041935 >98% 100mg $500 2021-12-16 Buy
DC Chemicals DC8617 JNJ-42041935 >98% 250mg $900 2021-12-16 Buy
DC Chemicals DC8617 JNJ-42041935 >98% 1g $1800 2021-12-16 Buy
TRC J211318 JNJ42041935 25mg $480 2021-12-16 Buy

Properties

Boiling point :555.9±60.0 °C(Predicted)
Density :1.82±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :3.52±0.10(Predicted)
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzymes act as central gatekeepers of posttranscriptional and transcriptional adaptation to hypoxia, oxidative stress, and excitotoxicity. Their catalytic activity is dependent on iron, 2-oxoglutarate (2-OG), and oxygen, and leads to the stabilization of a host of proteins, including the hypoxia-inducible transcription factors in response to oxygen availability. Inhibitors of PHD have been used to mimic a hypoxic response in order to study a range of oxygen-deprivation-related disorders, including anemia, ulcerative colitis, myocardial ischemia, stroke, and metabolic disorders. JNJ-42041935 is a selective, 2-OG competitive, and reversible inhibitor of PHD enzymes (pKis = 7.91, 7.29, and 7.65 for PHD1, 2, and 3, respectively). It is >100-fold selective for PHD compared to the related FIH (factor-inhibiting HIF) and a panel of various other enzymes. In an inflammation-induced anemia model in rats, 100 μM/kg/day JNJ-42041935 significantly increased the number of circulating reticulocytes and red blood cells, increased blood hemoglobin and hematocrit, and restored mean corpuscular volume and mean cell hemoglobin of red bloods cells.