5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
![5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime price.](/CAS2/GIF/405554-55-4.gif)
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- $49 - $11166
- Product name: 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
- CAS: 405554-55-4
- MF: C27H27N5O2
- MW: 453.54
- EINECS:
- MDL Number:MFCD16038645
- Synonyms:5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime;1H-Inden-1-one, 5-[2-[4-[2-(diMethylaMino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-iMidazol-4-yl]-2,3-dihydro-, oxiMe;GSK 2118436(SB 590885);SB590885(GSK2118436);5-[2-[4-[2-(DiMethylaMino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-iMidazol-4-yl]-2,3-dihydro-1H-inden-1-on;(E)-5-(2-(4-(2-(dimethylamino)ethoxy)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5-yl)-2,3-dihydroinden-1-one oxime;SB590885;GSK 2118436
45 prices
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Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Labseeker
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
Package
- 5mg
- 10
- 1mg
- 10mg
- 25mg
- 2x25mg
- 50mg
- 50
- 10mM(in 1mL DMSO)
- 100mg
- 250mg
- 1000mg
- 1g
- 10g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1077-M100
- Product descriptionSB590885 ≥95%
- Packaging100mg
- Price$1177
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0277
- Product descriptionSB-590885
- Packaging250mg
- Price$3047
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA720977
- Product description5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+%
- Packaging5mg
- Price$104
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA720977
- Product description5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+%
- Packaging10mg
- Price$176
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA720977
- Product description5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+%
- Packaging50mg
- Price$448
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA720977
- Product description5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+%
- Packaging100mg
- Price$672
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000231
- Product descriptionSB-590885 95.00%
- Packaging10MG
- Price$739.2
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000231
- Product descriptionSB-590885 95.00%
- Packaging50MG
- Price$1328.25
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1406
- Product descriptionSB590885
- Packaging10mM(in 1mL DMSO)
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1406
- Product descriptionSB590885
- Packaging50mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0159
- Product descriptionSB-590885
- Packaging1mg
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0159
- Product descriptionSB-590885
- Packaging5mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0159
- Product descriptionSB-590885
- Packaging10mg
- Price$203
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60336
- Product descriptionSB590885 ≥98%
- Packaging5mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2504
- Product descriptionSB590885 99%
- Packaging5mg
- Price$104.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2504
- Product descriptionSB590885 99%
- Packaging2x25mg
- Price$572
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1077-M100 | SB590885 ≥95% | 100mg | $1177 | 2021-12-16 | Buy |
| AK Scientific | Y0277 | SB-590885 | 250mg | $3047 | 2021-12-16 | Buy |
| Ambeed | A720977 | 5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+% | 5mg | $104 | 2021-12-16 | Buy |
| Ambeed | A720977 | 5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+% | 10mg | $176 | 2021-12-16 | Buy |
| Ambeed | A720977 | 5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+% | 50mg | $448 | 2021-12-16 | Buy |
| Ambeed | A720977 | 5-(2-(4-(2-(Dimethylamino)ethoxy)phenyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-oneoxime 98+% | 100mg | $672 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000231 | SB-590885 95.00% | 10MG | $739.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000231 | SB-590885 95.00% | 50MG | $1328.25 | 2021-12-16 | Buy |
| ApexBio Technology | B1406 | SB590885 | 10mM(in 1mL DMSO) | $150 | 2021-12-16 | Buy |
| ApexBio Technology | B1406 | SB590885 | 50mg | $480 | 2021-12-16 | Buy |
| Apolloscientific | BISN0159 | SB-590885 | 1mg | $66 | 2021-12-16 | Buy |
| Apolloscientific | BISN0159 | SB-590885 | 5mg | $124 | 2021-12-16 | Buy |
| Apolloscientific | BISN0159 | SB-590885 | 10mg | $203 | 2021-12-16 | Buy |
| Arctom | CFN60336 | SB590885 ≥98% | 5mg | $208 | 2021-12-16 | Buy |
| Axon Medchem | Axon2504 | SB590885 99% | 5mg | $104.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon2504 | SB590885 99% | 2x25mg | $572 | 2021-12-16 | Buy |
Properties
Density :1.27
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble2mg/mL (clear solution, warmed)
form :powder
color :white to beige
InChIKey :MLSAQOINCGAULQ-QLTSDVKISA-N
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble2mg/mL (clear solution, warmed)
form :powder
color :white to beige
InChIKey :MLSAQOINCGAULQ-QLTSDVKISA-N
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi. SB-590885 is a potent inhibitor of B-Raf (Kd = 0.3 nM). It less effectively inhibits c-Raf (Ki = 1.72 nM) and has little effect at 46 other kinases. SB-590885 blocks activation of ERK1/2 and anchorage-independent cell proliferation of melanoma cells with either wild type or V600E B-Raf at nanomolar concentrations. Melanoma cells expressing the B-RafV600E mutation can drive invasion through alternative pathways in the presence of SB-590885, suggesting that combination therapy is needed to completely block cell invasion. SB-590885 has also been used to study the role of B-Raf in cerebral ischemia.Related product price
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Suppliers and manufacturers
career henan chemical co
![5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime](https://img.chemicalbook.com/ProductImageEN/2018-12/small/0d29a12c-2ca6-431a-b0b8-b91eca49647d.png)
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Hubei xin bonus chemical co. LTD
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
$2.00 /1kg
5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime CAS:405554-55-4
5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime CAS:405554-55-4