CYSMETHYNIL
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- $81 - $417
- Product name: CYSMETHYNIL
- CAS: 851636-83-4
- MF: C25H32N2O
- MW: 376.53
- EINECS:
- MDL Number:MFCD22572757
- Synonyms:CYSMETHYNIL;2-[5-(3-methylphenyl)-1-octylindol-3-yl]acetamide;1H-Indole-3-acetamide, 5-(3-methylphenyl)-1-octyl-
6 prices
Selected condition：
Brand
- aablocks
- AK Scientific
- Cayman Chemical
Package
- 5mg
- 10mg
- 25mg
- Manufactureraablocks
- Product numberAA008G1D
- Product description1H-Indole-3-acetamide,5-(3-methylphenyl)-1-octyl- ≥98%
- Packaging25mg
- Price$417
- Updated2021-12-16
- Buy
- Manufactureraablocks
- Product numberAA008G1D
- Product description1H-Indole-3-acetamide,5-(3-methylphenyl)-1-octyl- ≥98%
- Packaging10mg
- Price$205
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4578CQ
- Product descriptionCysmethynil
- Packaging10mg
- Price$267
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14745
- Product descriptionCysmethynil ≥98%
- Packaging5mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14745
- Product descriptionCysmethynil ≥98%
- Packaging10mg
- Price$152
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14745
- Product descriptionCysmethynil ≥98%
- Packaging25mg
- Price$356
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA008G1D | 1H-Indole-3-acetamide,5-(3-methylphenyl)-1-octyl- ≥98% | 25mg | $417 | 2021-12-16 | Buy |
| aablocks | AA008G1D | 1H-Indole-3-acetamide,5-(3-methylphenyl)-1-octyl- ≥98% | 10mg | $205 | 2021-12-16 | Buy |
| AK Scientific | 4578CQ | Cysmethynil | 10mg | $267 | 2021-12-16 | Buy |
| Cayman Chemical | 14745 | Cysmethynil ≥98% | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 14745 | Cysmethynil ≥98% | 10mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 14745 | Cysmethynil ≥98% | 25mg | $356 | 2024-03-01 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMF: 3.3 mg/ml; DMSO: 5 mg/ml; Ethanol: 20 mg/ml
form :A crystalline solid
solubility :DMF: 3.3 mg/ml; DMSO: 5 mg/ml; Ethanol: 20 mg/ml
form :A crystalline solid
Safety Information
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Description
Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Isoprenylcysteine carboxyl methyltransferase (Icmt) catalyzes the methylation of C-terminal prenylcysteine residues, the last step in this process. Cysmethynil is an indole-based, time-dependent inhibitor of Icmt (IC50 = <200 nM). It acts as a competitive inhibitor with respect to the isoprenylated cysteine substrate and a noncompetitive inhibitor with respect to S-adenosylmethionine (Ki = 0.14 μM for the final complex). It does not inhibit other enzymes in the prenylation pathway (farensyltransferase, geranylgeranyltransferase type I, and Rce1) at concentrations up to 50 μM, or related methyltransferases. Treatment of cancer cells results in a dose-dependent decrease in Ras carboxylmethylation, mislocalization of Ras, and impaired signaling through Ras pathways. Treatment of PC3 prostate cancer cells with 25 μM cysmethynil resulted in decreased mTOR signaling, accumulation of cells in the G1 phase, and autophagy-mediated cell death.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Aladdin Scientific
Credit Asia Chemical Co., Ltd.
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Shanghai Rechem science Co., Ltd.
Shanghai Chaolan Chemical Technology Center
Shanghai Hongye Biotechnology Co. Ltd
Wuxi Donghe Pharmaceutical Technology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
MedBioPharmaceutical Technology Inc