Eltrombopag
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- $8 - $3686
- Product name: Eltrombopag
- CAS: 496775-61-2
- MF: C25H22N4O4
- MW: 442.47
- EINECS:610-469-9
- MDL Number:MFCD20926253
- Synonyms:(1,1'-Biphenyl)-3-carboxylic acid, 3'-((2Z)-(1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene)hydrazino)-2'-hydroxy-;Sb497115;Sb-497115;Unii-S56D65xj9g;(E)-3\'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2\'-hydroxybiphenyl-3-carboxylic acid;Eltrombopag;3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid;3-(5-{2-[2-(3,4-diMethylphenyl)-5-Methyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]hydrazin-1-ylidene}-6-oxocyclohexa-1,3-dien-1-yl)benzoic acid
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Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 1mg
- 2mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- 25g
- ManufacturerAK Scientific
- Product numberJ52723
- Product descriptionEltrombopag
- Packaging100mg
- Price$245
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX5021
- Product descriptionEltrombopag
- Packaging50mg
- Price$254
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA157281
- Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
- Packaging10mg
- Price$8
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA157281
- Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
- Packaging50mg
- Price$14
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA157281
- Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
- Packaging100mg
- Price$26
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA157281
- Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
- Packaging250mg
- Price$38
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA157281
- Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
- Packaging1g
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA157281
- Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
- Packaging5g
- Price$291
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA157281
- Product description(Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+%
- Packaging25g
- Price$969
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005198
- Product descriptionELTROMBOPAG 95.00%
- Packaging5MG
- Price$265.1
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005198
- Product descriptionELTROMBOPAG 95.00%
- Packaging50MG
- Price$2194.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB2159
- Product descriptionEltrombopag
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3013A
- Product descriptionEltrombopag
- Packaging10mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3013A
- Product descriptionEltrombopag
- Packaging25mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3013A
- Product descriptionEltrombopag
- Packaging100mg
- Price$229
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3013A
- Product descriptionEltrombopag
- Packaging1g
- Price$490
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | J52723 | Eltrombopag | 100mg | $245 | 2021-12-16 | Buy |
| AK Scientific | X5021 | Eltrombopag | 50mg | $254 | 2021-12-16 | Buy |
| Ambeed | A157281 | (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% | 10mg | $8 | 2021-12-16 | Buy |
| Ambeed | A157281 | (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% | 50mg | $14 | 2021-12-16 | Buy |
| Ambeed | A157281 | (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% | 100mg | $26 | 2021-12-16 | Buy |
| Ambeed | A157281 | (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% | 250mg | $38 | 2021-12-16 | Buy |
| Ambeed | A157281 | (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% | 1g | $95 | 2021-12-16 | Buy |
| Ambeed | A157281 | (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% | 5g | $291 | 2021-12-16 | Buy |
| Ambeed | A157281 | (Z)-3'-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacid 99+% | 25g | $969 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005198 | ELTROMBOPAG 95.00% | 5MG | $265.1 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005198 | ELTROMBOPAG 95.00% | 50MG | $2194.5 | 2021-12-16 | Buy |
| ApexBio Technology | B2159 | Eltrombopag | 10mg | $70 | 2021-12-16 | Buy |
| AvaChem | 3013A | Eltrombopag | 10mg | $75 | 2021-12-16 | Buy |
| AvaChem | 3013A | Eltrombopag | 25mg | $109 | 2021-12-16 | Buy |
| AvaChem | 3013A | Eltrombopag | 100mg | $229 | 2021-12-16 | Buy |
| AvaChem | 3013A | Eltrombopag | 1g | $490 | 2021-12-16 | Buy |
Properties
Melting point :242-244°C
Boiling point :656.8±65.0 °C(Predicted)
Density :1.33
storage temp. :Keep in dark place,Inert atmosphere,Room temperature
solubility :Soluble in DMSO (up to 55 mg/ml) or in ethanol (up to 14 mg/ml).
form :solid
pka :-1.26±0.40(Predicted)
color :Orange
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-
InChIKey :XDXWLKQMMKQXPV-QYQHSDTDSA-N
SMILES :C1(C2=CC=CC(N/N=C3\C(=O)N(C4=CC=C(C)C(C)=C4)N=C\3C)=C2O)=CC=CC(C(O)=O)=C1
Boiling point :656.8±65.0 °C(Predicted)
Density :1.33
storage temp. :Keep in dark place,Inert atmosphere,Room temperature
solubility :Soluble in DMSO (up to 55 mg/ml) or in ethanol (up to 14 mg/ml).
form :solid
pka :-1.26±0.40(Predicted)
color :Orange
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-
InChIKey :XDXWLKQMMKQXPV-QYQHSDTDSA-N
SMILES :C1(C2=CC=CC(N/N=C3\C(=O)N(C4=CC=C(C)C(C)=C4)N=C\3C)=C2O)=CC=CC(C(O)=O)=C1
Safety Information
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Description
ITP is an autoimmune disease in which antiplatelet antibodies accelerate the destruction of platelets. In addition, platelet production can be impaired because the antiplatelet antibodies can also damage megakaryocytes. Although the thrombocytopenia of ITP can be severe, signs of bleeding are usually only minor.Eltrombopag is an oral, small-molecule, nonpeptide TPO-receptor agonist. It initiates TPO-receptor signaling by interacting with the transmembrane domain of the receptor, thereby inducing proliferation and differentiation of cells in the megakaryocytic lineage. Eltrombopag is the second TPO-receptor agonist to reach the market behind romiplostim (Nplate), a recombinant fusion protein launched in 2008. Both drugs are specifically indicated for the treatment of thrombocytopenia in patients with chronic ITP who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. Eltrombopag is supplied as the ethanolamine salt (also known as eltrombopag olamine).
The most common adverse reactions associated with eltrombopag were nausea, vomiting, mennorrhagia, myalgia, paresthesia and cataracts. Eltrombopag is derived in five synthetic steps starting from 2-bromo-6-nitroanisole, via Suzuki coupling reaction with 3-carboxyphenylboronic acid to a biphenyl intermediate, followed by cleavage of the methyl ether moiety with hydrobromic acid, and reduction of the nitro group to an amino group under catalytic hydrogenation conditions. Subsequently, the amino group is diazotized with sodium nitrite and hydrochloric acid, and the diazonium intermediate is condensed with 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1H-pyrazol-5-one to produce eltrombopag.
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Suppliers and manufacturers
AFINE CHEMICALS LIMITED
Capot Chemical Co.,Ltd.
Henan Tianfu Chemical Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.
Shanghai Yingrui Biopharma Co., Ltd.
