Paprotrain
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- $32 - $725
- Product name: Paprotrain
- CAS: 57046-73-8
- MF: C16H11N3
- MW: 245.28
- EINECS:
- MDL Number:
- Synonyms:Paprotrain;(alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile;2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile;(Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile;1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-;Kinesin,Paprotrain,Inhibitor,inhibit;(Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile
23 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- ChemScene
- CSNpharm
- Tocris
- TRC
- Usbiological
Package
- 50
- 10
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3504-M001
- Product descriptionPaprotrain ≥98%(NMR)
- Packaging1mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4300CT
- Product descriptionPaprotrain
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4300CT
- Product descriptionPaprotrain
- Packaging10mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7713
- Product descriptionPaprotrain
- Packaging5mg
- Price$87
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7713
- Product descriptionPaprotrain
- Packaging10mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7713
- Product descriptionPaprotrain
- Packaging25mg
- Price$229
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7713
- Product descriptionPaprotrain
- Packaging50mg
- Price$410
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7713
- Product descriptionPaprotrain
- Packaging100mg
- Price$725
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10524
- Product descriptionPaprotrain ≥95%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10524
- Product descriptionPaprotrain ≥95%
- Packaging5mg
- Price$56
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10524
- Product descriptionPaprotrain ≥95%
- Packaging10mg
- Price$78
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-6861
- Product descriptionPaprotrain 99.54%
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6861
- Product descriptionPaprotrain 99.54%
- Packaging10mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6861
- Product descriptionPaprotrain 99.54%
- Packaging25mg
- Price$144
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6861
- Product descriptionPaprotrain 99.54%
- Packaging50mg
- Price$228
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6861
- Product descriptionPaprotrain 99.54%
- Packaging100mg
- Price$408
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3504-M001 | Paprotrain ≥98%(NMR) | 1mg | $90 | 2021-12-16 | Buy |
| AK Scientific | 4300CT | Paprotrain | 1mg | $133 | 2021-12-16 | Buy |
| AK Scientific | 4300CT | Paprotrain | 10mg | $185 | 2021-12-16 | Buy |
| ApexBio Technology | B7713 | Paprotrain | 5mg | $87 | 2021-12-16 | Buy |
| ApexBio Technology | B7713 | Paprotrain | 10mg | $122 | 2021-12-16 | Buy |
| ApexBio Technology | B7713 | Paprotrain | 25mg | $229 | 2021-12-16 | Buy |
| ApexBio Technology | B7713 | Paprotrain | 50mg | $410 | 2021-12-16 | Buy |
| ApexBio Technology | B7713 | Paprotrain | 100mg | $725 | 2021-12-16 | Buy |
| Cayman Chemical | 10524 | Paprotrain ≥95% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 10524 | Paprotrain ≥95% | 5mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 10524 | Paprotrain ≥95% | 10mg | $78 | 2024-03-01 | Buy |
| ChemScene | CS-6861 | Paprotrain 99.54% | 5mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-6861 | Paprotrain 99.54% | 10mg | $84 | 2021-12-16 | Buy |
| ChemScene | CS-6861 | Paprotrain 99.54% | 25mg | $144 | 2021-12-16 | Buy |
| ChemScene | CS-6861 | Paprotrain 99.54% | 50mg | $228 | 2021-12-16 | Buy |
| ChemScene | CS-6861 | Paprotrain 99.54% | 100mg | $408 | 2021-12-16 | Buy |
Properties
Melting point :202℃
storage temp. :2-8°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml; Ethanol: 0.2 mg/ml
form :Powder
storage temp. :2-8°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml; Ethanol: 0.2 mg/ml
form :Powder
Safety Information
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Description
Mitotic kinesin-like protein 2 (MKLP-2) is an N-terminal motor from the kinesin-6 family that is essential for normal cleavage furrow ingression and cytokinesis. Its activity mediates the relocation of the chromosome passenger proteins Aurora B kinase and survivin from the centromeres to the central spindle in anaphase cells in order to facilitate cytokinesis, avoiding the generation of binucleated cells. Paprotrain, PAssenger PROteins TRAnsport INhibitor, is the first known inhibitor of MKLP-2. It is a cell-permeable, reversible inhibitor uncompetitive with ATP (Ki = 3.4 μM) and noncompetitive with microtubules (Ki = 1.6 μM), demonstrating ATPase inhibition of basal and microtubule-stimulated activities with IC50 values of 1.35 and 0.83 μM, respectively. Paprotrain does not inhibit twelve additional kinesins, including the closely related kinesin-6 motors MKLP-1 and MPP1. Incubation with 10-50 μM paprotrain results in binucleated cells, perturbing relocation of Aurora B kinase and survivin without affecting microtubule polymerization.Related product price
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