Refametinib
|
- $38 - $2500
- Product name: Refametinib
- CAS: 923032-37-5
- MF: C19H20F3IN2O5S
- MW: 572.34
- EINECS:
- MDL Number:MFCD18633256
- Synonyms:RDEA119;BAY-869766;RefaMetinib;RDEA-119 (BAY-869766);BAY 8697661;RefaMetinib/BAY 8697661;N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide;(S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide
27 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Arctom
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5691
- Product descriptionRDEA119
- Packaging100mg
- Price$931
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1267
- Product descriptionRefametinib
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1267
- Product descriptionRefametinib
- Packaging10mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1267
- Product descriptionRefametinib
- Packaging50mg
- Price$290
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1267
- Product descriptionRefametinib
- Packaging100mg
- Price$470
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1267
- Product descriptionRefametinib
- Packaging200mg
- Price$760
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60397
- Product descriptionRefametinib(RDEA119)
- Packaging10mg
- Price$208
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR104239
- Product descriptionRefametinib
- Packaging10mg
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR104239
- Product descriptionRefametinib
- Packaging50mg
- Price$507.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16997
- Product descriptionRefametinib ≥95%
- Packaging1mg
- Price$38
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16997
- Product descriptionRefametinib ≥95%
- Packaging5mg
- Price$111
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16997
- Product descriptionRefametinib ≥95%
- Packaging10mg
- Price$166
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16997
- Product descriptionRefametinib ≥95%
- Packaging50mg
- Price$547
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-1818
- Product descriptionRefametinib 99.82%
- Packaging5mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1818
- Product descriptionRefametinib 99.82%
- Packaging10mg
- Price$144
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1818
- Product descriptionRefametinib 99.82%
- Packaging50mg
- Price$372
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5691 | RDEA119 | 100mg | $931 | 2021-12-16 | Buy |
| ApexBio Technology | B1267 | Refametinib | 5mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | B1267 | Refametinib | 10mg | $105 | 2021-12-16 | Buy |
| ApexBio Technology | B1267 | Refametinib | 50mg | $290 | 2021-12-16 | Buy |
| ApexBio Technology | B1267 | Refametinib | 100mg | $470 | 2021-12-16 | Buy |
| ApexBio Technology | B1267 | Refametinib | 200mg | $760 | 2021-12-16 | Buy |
| Arctom | CFN60397 | Refametinib(RDEA119) | 10mg | $208 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR104239 | Refametinib | 10mg | $145 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR104239 | Refametinib | 50mg | $507.5 | 2021-12-16 | Buy |
| Cayman Chemical | 16997 | Refametinib ≥95% | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 16997 | Refametinib ≥95% | 5mg | $111 | 2024-03-01 | Buy |
| Cayman Chemical | 16997 | Refametinib ≥95% | 10mg | $166 | 2024-03-01 | Buy |
| Cayman Chemical | 16997 | Refametinib ≥95% | 50mg | $547 | 2024-03-01 | Buy |
| ChemScene | CS-1818 | Refametinib 99.82% | 5mg | $96 | 2021-12-16 | Buy |
| ChemScene | CS-1818 | Refametinib 99.82% | 10mg | $144 | 2021-12-16 | Buy |
| ChemScene | CS-1818 | Refametinib 99.82% | 50mg | $372 | 2021-12-16 | Buy |
Properties
Boiling point :566.9±60.0 °C(Predicted)
Density :1.82±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥151.8 mg/mL in DMSO; ≥90.2 mg/mL in EtOH
form :Powder
pka :15.54±0.20(Predicted)
Density :1.82±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥151.8 mg/mL in DMSO; ≥90.2 mg/mL in EtOH
form :Powder
pka :15.54±0.20(Predicted)
Safety Information
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| Signal word: | Danger | ||||||||||||||||||||||
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Description
Refametinib is an allosteric, selective inhibitor of MEK1 and MEK2 (IC50s = 19 and 47 nM, respectively). It blocks phosphorylation of ERK1/2 across several human cancer cell lines differing in tissue origin and BRAF mutational status (EC50s = 2.5-16 nM), inhibiting cell cycling in cancer cells but not in primary cells. Refametinib is orally available and active in human tumor xenograft models. It has potential utility, particularly in combination therapy, in certain forms of cancer.Related product price
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$28-1208.7
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