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ChemicalBook >> CAS DataBase List >> Regorafenib-13C-d3

Regorafenib-13C-d3

Regorafenib-13C-d3 price.
  • $242 - $610
  • Product name: Regorafenib-13C-d3
  • CAS: 2126178-55-8
  • MF: C21H12ClD3F4N4O3
  • MW: 486.842898134
  • EINECS:
  • MDL Number:MFCD28343980
  • Synonyms:Regorafenib-13C-d3;4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-(methyl-13C-d3)-2-pyridinecarboxamide
3 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
Package
  • 500μg
  • 1mg
  • ManufacturerAK Scientific
  • Product number0135DY
  • Product description4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-(trideuterio(113C)methyl)pyridine-2-carboxamide
  • Packaging1mg
  • Price$610
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25486
  • Product descriptionRegorafenib-13C-d3 ≥99% deuterated forms (d1-d3)
  • Packaging500μg
  • Price$242
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25486
  • Product descriptionRegorafenib-13C-d3 ≥99% deuterated forms (d1-d3)
  • Packaging1mg
  • Price$459
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 0135DY 4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-(trideuterio(113C)methyl)pyridine-2-carboxamide 1mg $610 2021-12-16 Buy
Cayman Chemical 25486 Regorafenib-13C-d3 ≥99% deuterated forms (d1-d3) 500μg $242 2024-03-01 Buy
Cayman Chemical 25486 Regorafenib-13C-d3 ≥99% deuterated forms (d1-d3) 1mg $459 2024-03-01 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 14 mg/ml
form :A solid

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Regorafenib-13C-d3 is intended for use as an internal standard for the quantification of regorafenib by GC- or LC-MS. Regorafenib is an orally bioavailable multi-kinase inhibitor with anticancer activity.1 It inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ with IC50 values of 1.5, 2.5, 4.2, 7, 13, and 22 nM, respectively. Regorafenib also inhibits B-RAF, VEGFR3, FGFR, and Tie2 (IC50s = 28, 46, 202, and 311 nM, respectively) as well as other kinases.1,2,3 In vivo, regorafenib (10 mg/kg) reduces tumor size in the MDA-MB-231 breast and 786-O renal cancer mouse xenograft models.1 It also reduces tumor microvessel area and inhibits tumor growth in a panel of mouse xenograft models. Formulations containing regorafenib have been used in the treatment of advanced gastrointestinal stromal tumors and metastatic colorectal cancer.