Riociguat
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- $7 - $2660
- Product name: Riociguat
- CAS: 625115-55-1
- MF: C20H19FN8O2
- MW: 422.42
- EINECS:641-755-1
- MDL Number:MFCD19443708
- Synonyms:Riociguat;N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester;Bay 63-2521;Carbamic acid, (4,6-diamino-2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-B)pyridin-3-yl)-5-pyrimidinyl)methyl-, methyl ester;Riociguat (BAY 63-2521);Bay63-2521,Riociguat;[4,6-DiaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]MethylcarbaMic acid Methyl ester;Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate
38 prices
Selected condition：
Brand
- AccelPharmtech
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1000mg
- 1g
- 2g
- 5G
- 10G
- 25G
- 50G
- 100G
- ManufacturerAccelPharmtech
- Product numberXP2357
- Product descriptionRiociguat 99.00%
- Packaging5G
- Price$230
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberXP2357
- Product descriptionRiociguat 99.00%
- Packaging10G
- Price$390
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberXP2357
- Product descriptionRiociguat 99.00%
- Packaging25G
- Price$820
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberXP2357
- Product descriptionRiociguat 99.00%
- Packaging50G
- Price$2340
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberXP2357
- Product descriptionRiociguat 99.00%
- Packaging100G
- Price$2660
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ97348
- Product descriptionRiociguat
- Packaging5g
- Price$395
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255332
- Product descriptionMethyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+%
- Packaging1mg
- Price$7
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255332
- Product descriptionMethyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+%
- Packaging5mg
- Price$11
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255332
- Product descriptionMethyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+%
- Packaging10mg
- Price$14
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255332
- Product descriptionMethyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+%
- Packaging50mg
- Price$23
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255332
- Product descriptionMethyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+%
- Packaging100mg
- Price$30
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255332
- Product descriptionMethyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+%
- Packaging250mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255332
- Product descriptionMethyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+%
- Packaging1g
- Price$148
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA255332
- Product descriptionMethyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+%
- Packaging5g
- Price$396
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0010348
- Product descriptionRIOCIGUAT 95.00%
- Packaging1G
- Price$376.95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3767
- Product descriptionRiociguat
- Packaging50mg
- Price$315
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AccelPharmtech | XP2357 | Riociguat 99.00% | 5G | $230 | 2021-12-16 | Buy |
| AccelPharmtech | XP2357 | Riociguat 99.00% | 10G | $390 | 2021-12-16 | Buy |
| AccelPharmtech | XP2357 | Riociguat 99.00% | 25G | $820 | 2021-12-16 | Buy |
| AccelPharmtech | XP2357 | Riociguat 99.00% | 50G | $2340 | 2021-12-16 | Buy |
| AccelPharmtech | XP2357 | Riociguat 99.00% | 100G | $2660 | 2021-12-16 | Buy |
| AK Scientific | J97348 | Riociguat | 5g | $395 | 2021-12-16 | Buy |
| Ambeed | A255332 | Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+% | 1mg | $7 | 2021-12-16 | Buy |
| Ambeed | A255332 | Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+% | 5mg | $11 | 2021-12-16 | Buy |
| Ambeed | A255332 | Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+% | 10mg | $14 | 2021-12-16 | Buy |
| Ambeed | A255332 | Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+% | 50mg | $23 | 2021-12-16 | Buy |
| Ambeed | A255332 | Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+% | 100mg | $30 | 2021-12-16 | Buy |
| Ambeed | A255332 | Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+% | 250mg | $60 | 2021-12-16 | Buy |
| Ambeed | A255332 | Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+% | 1g | $148 | 2021-12-16 | Buy |
| Ambeed | A255332 | Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 98+% | 5g | $396 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010348 | RIOCIGUAT 95.00% | 1G | $376.95 | 2021-12-16 | Buy |
| ApexBio Technology | A3767 | Riociguat | 50mg | $315 | 2021-12-16 | Buy |
Properties
Melting point :247-251°C (dec.)
Boiling point :567.2±50.0 °C(Predicted)
Density :1.51
storage temp. :Refrigerator
solubility :DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka :1.51±0.50(Predicted)
form :Solid
color :Off-White to Orange
Boiling point :567.2±50.0 °C(Predicted)
Density :1.51
storage temp. :Refrigerator
solubility :DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka :1.51±0.50(Predicted)
form :Solid
color :Off-White to Orange
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
In September 2013, Health Canada approved riociguat (also referred to as BAY 63-2521), for the treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) after surgical treatment or inoperable CTEPH and for the treatment of adults with pulmonary arterial hypertension (PAH). Riociguat has a dual mode of action and works by (a) sensitizing sGC to the body’s NO by stabilizing NO–sGC binding and (b) an NO-independent, direct stimulation of sGC via a different binding site. This process restores the NO–sGC–cGMP pathway and leads to increased generation of cGMP with subsequent vasodilation.Headache, dizziness, dyspepsia/gastritis, nausea, diarrhea, hypotension, vomiting, anemia, gastroesophageal reflux, and constipation were the most common adverse events ( 3%) observed during riociguat clinical trials. Riociguat comes with a black box warning for embryo-fetal toxicity.
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