8-アジド-5,6-ジヒドロ-5-メチル-6-オキソ-4H-イミダゾ[1,5-a][1,4]ベンゾジアゼピン-3-カルボン酸エチル

プロパティ

安全情報

説明

RO 15-4513 is a high affinity benzodiazepine ligand which acts as a partial inverse agonist at recombinant diazepam-sensitive (DS) benzodiazepine α1-, α2-, α3- and α5-GABA_A receptors. It has also been shown to activate GABA_A R α4 and GABA_A R α6. In addition, RO 15-4513 acts as a partial agonist at diazepam-insensitive (DI) benzodiazepine receptors. Furthermore, studies show that ethanol can inhibit the binding of RO 15-4513 to α4/6β3δ GABA_A receptors. RO 15-4513 has a similar structure to flumazenil, which differs by an azido group at the C7 position of the imidazo-benzodiazepine ring.