| | 604-59-1 Basic information More.. |
| Product Name: | α-Naphthoflavone | | Synonyms: | 7,8-BENZOFLAVONE;ALPHA-NAPHTHOFLAVONE;A-NAPHTHOFLAVANONE;A-NAPHTHOFLAVONE;BENZOFLAVONE;NAPHTHOFLAVANONE, A-;NAPHTHOFLAVONE, A-;2-b)pyran-4-one,2-phenyl-4h-naphtho( | | CAS: | 604-59-1 | | MF: | C19H12O2 | | MW: | 272.3 | | EINECS: | 210-071-1 | | Mol File: | 604-59-1.mol |  |
Use
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.[Cayman Chemical]
- α-Naphthoflavone
-
- US $0.00 / kg
- 2023-11-14
- CAS:604-59-1
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 20 tons
- α-Naphthoflavone
-
- US $0.00 / KG
- 2023-11-13
- CAS:604-59-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- α-Naphthoflavone
-
- US $30.00-10.00 / KG
- 2023-09-06
- CAS:604-59-1
- Min. Order: 50KG
- Purity: 99%
- Supply Ability: 500000kg
|
|
604-59-1
Recommend Suppliers |
|