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Product Name:11(12)-EpETE
Synonyms:11(12)-EpETE;11,12-epoxy-5(Z),8(Z),14(Z),17(Z)- eicosatetraenoic acid;5,8-Decadienoic acid, 10-[3-(2Z,5Z)-2,5-octadien-1-yl-2-oxiranyl]-, (5Z,8Z)-;11(12)-EpETE Exclusive
CAS:504435-15-8
MF:C20H30O3
MW:318.45
EINECS:
Mol File:504435-15-8.mol
504435-15-8

Use

Eicosapentaenoic acid (EPA; ) is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE , relaxes vascular and airway smooth muscle by binding large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKα channel subunits. (±)11(12)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo. The biological actions and physiological effects of this epoxide remain to be determined.[Cayman Chemical]

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