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Product Name:Epothilone D
Synonyms:Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (4S,7R,8S,9S,13Z,16S)-;Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl -16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)-, (4S-(4R*,7S,8R*,9R*,1 3Z,16R*(E)))-;(3S,7S,14S,15S,16R)-3,15-Dihydroxy-2,2,10,14,16-pentamethyl-7-[1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-6-oxacyclohexadec-9-ene-1,5-dione;Epothilone D;Desoxyepothilone B;(4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentaMethyl-16-[(1E)-1-Methyl-2-(2-Methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione;12,13-Desoxyepothilone B;Epo D
CAS:189453-10-9
MF:C27H41NO5S
MW:491.68
EINECS:
Mol File:189453-10-9.mol
189453-10-9

Use

Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.

Epothilone D manufacturers

  • Epothilone D USP/EP/BP
  • US $1.10 / g
  • 2021-07-03
  • CAS:189453-10-9
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons Min
  • Epothilone D
  • US $0.00-0.00 / Kg
  • 2020-05-03
  • CAS:189453-10-9
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 800 ton
  • Epothilone D
  • US $0.00-0.00 / Kg
  • 2020-05-03
  • CAS:189453-10-9
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 800 ton
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