| | 79794-75-5 Basic information More.. |
| Product Name: | Loratadine | | Synonyms: | LORATADINE;LORATADINE-D5;4-(8-Chloro-10,11-dihydro-4-aza-5H-dibenzo[a,d]cycloheptene-5-ylidene)piperidine-1-carboxylic acid ethyl ester;4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridine-11-ylidene)piperidine-1-carboxylic acid ethyl ester;Loratadine,4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, Loratidine;anium wilfordii Maxim;4(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLATE;4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER | | CAS: | 79794-75-5 | | MF: | C22H23ClN2O2 | | MW: | 382.88 | | EINECS: | 935-907-9 | | Mol File: | 79794-75-5.mol |  |
Use
Loratadine, 4-(8-chloro-5,6-dihydro-11Hbenzo[5,6]-cyclohepta[1,2-b]pyridin-l 1-ylidene-1-carboxylic acid ethyl ester, is a white to off-white powder insoluble in water but very soluble in acetone, alcohols, and chloroform. Loratadine is structurally related to the antihistamines azatadine and cyproheptadine, and to some tricyclic antidepressants. It differs from azatadine, in that a neutral carbamate group has replaced the basic tertiary amino moiety, and a phenyl ring has been substituted with a chlorine atom. Loratadine is a selective peripheral H1-antihistamine with a receptor-binding profile like that of the other members of this series, except that it has more antiserotonergic activity. Thus, it produces no substantial CNS or autonomic side effects or cardiac toxicity. Loratadine displays potency comparable with that of astemizole and greater than that of terfenadine. Loratadine is indicated for the relief of nasal and nonnasal symptoms of seasonal allergic rhinitis. In the presence of a CYP3A4 inhibitor ketoconazole, loratadine is metabolized to descarboethoxyloratadine predominantly by CYP2D6.
- Loratadine
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- US $15.00 / kg
- 2024-04-29
- CAS:79794-75-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 300tons
- Loratadine
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- US $30.00 / kg
- 2024-04-28
- CAS:79794-75-5
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 2000kg
- Loratadine
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- US $0.00-0.00 / Kg/Bag
- 2024-04-22
- CAS:79794-75-5
- Min. Order: 1Kg/Bag
- Purity: 0.99
- Supply Ability: 20 tons
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79794-75-5
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