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Product Name:Tacrolimus
Synonyms:(2-propenyl)-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*;,19s*,26ar*))-;16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;L 679934;FK-506：FR-900506;Fujimycin Prozraf;Tacrolimus,micronisedandpharmagrade
CAS:104987-11-3
MF:C44H69NO12
MW:804.02
EINECS:1308068-626-2
Mol File:104987-11-3.mol
104987-11-3

Use

FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system. Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα.

Tacrolimus manufacturers

  • Tacrolimus
  • US $10.00 / kg
  • 2024-04-27
  • CAS:104987-11-3
  • Min. Order: 1kg
  • Purity: 99.8%
  • Supply Ability: 10000ton
  • Tacrolimus
  • US $50.00-40.00 / kg
  • 2024-04-26
  • CAS:104987-11-3
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 20Tons
  • Tacrolimus
  • US $0.00-0.00 / KG
  • 2024-04-24
  • CAS:104987-11-3
  • Min. Order: 1KG
  • Purity: 99
  • Supply Ability: 50000KG/month
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