3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇
| 中文名称 | 3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇 |
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| 中文同义词 | 螺二茚满;3,3,3',3'-四甲基螺环二酚;3,3,3',3'-四甲基-2,2',3,3'-四氢-1,1'-螺二[茚满]-6,6'-二醇;螺双茚满;3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇;3,3,3',3'-四甲基-2,2',3,3'-四氢-1,1'-螺联[茚]-6,6'-二醇;HIV-1整合酶抑制剂8;3,3,3,3-四甲基-2,2,3,3-四氢-1,1-螺双[茚]-6,6-二醇 |
| 英文名称 | SPIROBIINDANE |
| 英文同义词 | SPIROBIINDANE;2,2'',3,3''-TETRAHYDRO-3,3,3'',3''-TETRAMETHYL-1,1''-SPIROBI-1H-INDENE- 6,6''-DIOL;tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol;3,3,3',3'-Tetramethyl-1,1'-spirobi[indan]-6,6'-diol;3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro[1,1'-spirobi[1H-indene]]-6,6'-diol;3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-6,6'-diol;6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan;6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane |
| CAS号 | 1568-80-5 |
| 分子式 | C21H24O2 |
| 分子量 | 308.41 |
| EINECS号 | |
| 相关类别 | 醇;化学试剂 |
| Mol文件 | 1568-80-5.mol |
| 结构式 |  |
3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇 性质
| 熔点 | 213-214 °C |
|---|---|
| 沸点 | 478.5±45.0 °C(Predicted) |
| 密度 | 1.21±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：125 mg/mL（405.30 mM；需要超声波） |
| 酸度系数(pKa) | 9.98±0.60(Predicted) |
| CAS 数据库 | 1568-80-5 |
| EPA化学物质信息 | 1,1'-Spirobi[1H-indene]-6,6'-diol, 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl- (1568-80-5) |
HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn 2+ as the cationic cofactor by gel assay with IC 50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC 50 value of 200 µM.The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC 50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD 50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells.
安全信息
| 毒性 | rat,LD50,oral,> 5gm/kg (5000mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),International Journal of Toxicology. Vol. 19, Pg. 366, 2000. |
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