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| | 4,5-Dimethoxy-1-cyanobenzocyclobutane Basic information |
| Product Name: | 4,5-Dimethoxy-1-cyanobenzocyclobutane | | Synonyms: | 4,5-Dimethoxy-1-cyanobenzocyclobutane;Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile,3,4-diMethoxy-;4,5-DiMethxoy-1,2-dihydrocyclobutabenzene-1-carbonitrile;2-cyclobutyl-2-(3,4-diMethoxyphenyl)acetonitrile;3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-8-carbonitrile;1,2-Dihydro-4,5-diMethoxybenzocyclobutene-1-carbonitrile;NSC 154410;1-Cyano-4,5-dimethoxybenzocyclobutene | | CAS: | 35202-54-1 | | MF: | C11H11NO2 | | MW: | 189.21 | | EINECS: | 609-091-7 | | Product Categories: | | | Mol File: | 35202-54-1.mol |  |
| | 4,5-Dimethoxy-1-cyanobenzocyclobutane Chemical Properties |
| Melting point | 83-84 °C | | Boiling point | 345.9±42.0 °C(Predicted) | | density | 1.18 | | vapor pressure | 0.004Pa at 25℃ | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO, Methanol | | form | Solid | | color | Light Brown | | LogP | 1.22 at 30℃ and pH7 | | CAS DataBase Reference | 35202-54-1(CAS DataBase Reference) |
| | 4,5-Dimethoxy-1-cyanobenzocyclobutane Usage And Synthesis |
| Uses | 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile is used in the preparation of selective bradycardic agents. | | Uses | 4,5-Dimethoxy-1-cyanobenzocyclobutane is used in the preparation of selective bradycardic agents. | | Synthesis | NaNH2 (39.0 g,
1.0 mol) was added in portions to a solution of hydrocinnamonitrile
8 (224.0 g, 0.83 mol) in liquid ammonia at -45°C, and the reaction
mixture was stirred at -45 °C for 2 h. After evaporation of the excess
NH3, NH4Cl (20.0 g) and water (1000 mL) were added in portions.
After standing at room temperature, greyish crystals separated
and were collected and recrystallised with ethanol to give 4,5-Dimethoxy-1-cyanobenzocyclobutane as a colourless powder. Yield 116.5 g (74%). |
| | 4,5-Dimethoxy-1-cyanobenzocyclobutane Preparation Products And Raw materials |
| Raw materials | (E)-3-(3,4-dimethoxyphenyl)acrylonitrile-->3-(3,4-Dimethoxyphenyl)propanenitrile
-->3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-one-->3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANENITRILE-->4,5-dimethoxy-2-methylbenzaldehyde-->4,5-DIBROMOVERATROLE-->2-Bromo-4,5-Dimethoxybenzyl Bromide-->4-Bromoveratrole-->3,4-Dimethoxybenzyl alcohol-->Veratraldehyde-->1,2-Dimethoxybenzene | | Preparation Products | (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride-->(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride-->C-(3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1(6),2,4-TRIEN-7-YL)-METHYLAMINE |
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