壳聚糖低聚乳酸酯
中文名称 | 壳聚糖低聚乳酸酯 |
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中文同义词 | 壳聚糖寡糖乳酸;壳聚糖低聚乳酸酯;壳聚糖寡糖HCL;壳寡糖厂家;壳寡糖价格;壳寡糖生产厂家;壳寡糖作用;食品级壳寡糖 |
英文名称 | CHITOSAN OLIGOSACCHARIDE LACTATE |
英文同义词 | CHITOSAN OLIGOSACCHARIDE LACTATE;Chitosan 2-hydroxypropanoate (ester);Chitosan lactate (ester);Chitosan oligosaccharide lactate average Mn 5,000;Chitosan oligosaccharide HCl;Chitosan oligosaccharide (COS);Chitosan oligosaccharide,chito-oligosaccharide;Chitosan Olibosaccharide |
CAS号 | 148411-57-8 |
分子式 | C12H24N2O9 |
分子量 | 340.32696 |
EINECS号 | 251-228-4 |
相关类别 | 营养剂;医药原料;营养强化剂;甜味剂;有机化工原料;原料;对照品;Chitins and Chitosans;Natural Polymers;Polymer Science;Chitosan;Chitosan and Chitin;Materials Science;Natural Polymers;Polymer Science;Polymers |
Mol文件 | 148411-57-8.mol |
结构式 |
壳聚糖低聚乳酸酯 性质
储存条件 | Store at RT |
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形态 | 固体 |
颜色 | 浅黄至黄色 |
水溶解性 | Water : 50 mg/mL ;DMSO : 50 mg/mL |
食品级壳寡糖是由2-15个氨基葡萄糖单元构成的低聚糖,其医药、农业、轻工业等领域的广泛的功能已经得到学术界和市场的普遍认可。
Chitosan oligosaccharide (COS) 是一种 由 β-(1→4) 糖苷键连接的 D-葡糖胺的寡聚物。Chitosan oligosaccharide (COS) 激活 AMPK 并抑制包括 NF-κB 和 MAPK 途径的炎症信号途径。AMPK
Chitosan oligosaccharide (COS) represents a class of natural polymers that holds therapeutic promise in several diseases due to not only its physiochemical properties including water-solubility and low viscosity but also its favorable pharmacological properties including good pharmacokinetics and safety profiles and diverse beneficial biological activities. Activation of AMPK and inhibition of inflammatory signaling pathways including NF-κB and MAPK pathways are recognized as major mechanisms responsible for several effects of Chitosan oligosaccharide (COS) including anti-inflammation, anti-cancer, and anti-diabetes. COS can interrupt cancer progression at multiple stages by modulating several signaling proteins/pathways including NF-κB, AMPK, mTOR, caspase-3, CD147, MMP-2, MMP-9, and VEGF. In vitro experiments have demonstrated that Chitosan oligosaccharide (COS) induced the death of several cancer cell types including ascites, bladder cancer, prostate cancer, lung cancer, liver cancer, leukemia, cervical cancer and colorectal cancer. The values of IC 50 of Chitosan oligosaccharide (COS) in inducing cytotoxicity are 25 μg/mL-50 μg/mL depending on types of cancer cells.
The oral administration of Chitosan oligosaccharide (16 mg/kg/day) suppresses the production of the proinflammatory cytokines involved in allergic reactions, i.e., IL-4, IL-13 and TNF-α, in the lung tissues and bronchoalveolar lavage fluid of the mice. Last, an anti-inflammatory effect of Chitosan oligosaccharide (COS) on lymphocyte activation has been documented in a rat model of autoimmune anterior uveitis induced by immunization with bovine melanin-associated antigen. Chitosan oligosaccharide (COS) inhibits UV-induced macroscopic appearance in mice skin. Compared with healthy dorsal skin with smoothness and some shallow wrinkles of hairless mice in normal control group, UV exposure for 10 weeks triggers skin erythema, dry, thickening, sagging and coarse wrinkles, and even leathery appearance and slight flesh-colored lesion in the model mice, the visual score of which is markedly higher than that of the normal control group (p<0.05), indicating that UV induces photoaging in skin surface.
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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