MYRIOCIN

MYRIOCIN Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:6-Eicosenoic acid,2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-, (2S,3R,4R,6E)-
CAS:35891-70-4
Purity:99% Package:25KG;5KG;1KG
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Myriocin
CAS:35891-70-4
Purity:98.00% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;5 mg;50 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: BOC Sciences
Tel: +16314854226
Email: inquiry@bocsci.com
Products Intro: Product Name:Myriocin
CAS:35891-70-4
Purity:>97% by HPLC Remarks:BOC Sciences also provides custom synthesis services for Myriocin.
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
Tel: +undefined18621343501
Email: product@acmec-e.com
Products Intro: Product Name:Myriocin
CAS:35891-70-4
Purity:98% Package:5mg, 10mg
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:Myriocin, 99%, from Mycelia sterilia
CAS:35891-70-4
Purity:99% Package:5MG
MYRIOCIN Basic information
Product Name:MYRIOCIN
Synonyms:MYRIOCIN;MYRIOCIN, MYCELIA STERILIA;THERMOZYMOCIDIN;6e))-4s*;6-eicosenoicacid,2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-,(2s-(2r*,3s;[2S,3R,4R,6E]-2-AMINO-3,4-DIHYDROXY-2-[HYDROXYMETHYL]-14-OXO-6-EICOSENOIC ACID;[2S,3R,4R]-(E)-2-AMINO-3,4-DIHYDROXY-2-[HYDROXYMETHYL]-14-OXO-6-EICOSENOIC ACID;ISP-I
CAS:35891-70-4
MF:C21H39NO6
MW:401.54
EINECS:636-862-5
Product Categories:antibiotic
Mol File:35891-70-4.mol
MYRIOCIN Structure
MYRIOCIN Chemical Properties
Melting point 170-172℃
Boiling point 636.7±55.0 °C(Predicted)
density 1.123±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility methanol: 2 mg/mL
form powder
pka1.79±0.50(Predicted)
color off-white
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKeyZZIKIHCNFWXKDY-XFXZXTDPSA-N
CAS DataBase Reference35891-70-4
Safety Information
Hazard Codes Xi,Xn
Risk Statements 22
Safety Statements 24/25
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS JX3890000
HS Code 29225090
MSDS Information
ProviderLanguage
SigmaAldrich English
MYRIOCIN Usage And Synthesis
DescriptionMyriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus in a murine model.
Chemical PropertiesWhite powder
UsesMyriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus in a murine model.[Cayman Chemical]
UsesMyriocin is an α-amino fatty acid derived from several genera of fungi, notably Myriococcum, Melanconis and Isaria. Myriocin potently inhibits sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase. Myriocin induces apoptosis by depleting cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant.
UsesMyriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin i s a useful biochemical research tool for depleting cells of sphingolipids.
DefinitionChEBI: An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity.
General DescriptionA potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
Biochem/physiol ActionsProduct does not compete with ATP.
References1) Fujita et al.(1994) Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite; J. Antibiot. 47 208 2) Miyake et al. (1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant ISP-1/myriocin; Biochem. Biophys. Res. Commun. 211 396 3) Lee et al. (2012) Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis; Cancer Biol Ther. 13 92
MYRIOCIN Preparation Products And Raw materials
Tag:MYRIOCIN(35891-70-4) Related Product Information
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