氢溴酸非诺特罗
中文名称 | 氢溴酸非诺特罗 |
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中文同义词 | 氢溴酸芬忒醇;氢溴酸非诺特罗;甲醇中菲诺特罗溶液标准物质;氢溴酸非诺特罗非诺特罗 氢溴酸盐;5-[1-羟基-2-[[2-(4-羟基苯基)-1-甲基乙基]氨基]乙基]-1,3-苯二醇;氢溴酸菲诺特罗;氢溴酸菲诺特罗标准溶液;氢溴酸非诺特罗/酚丙喘宁芬忒醇 |
英文名称 | FENOTEROL HYDROBROMIDE |
英文同义词 | FENOTEROL HBR;FENOTEROL HYDROBROMIDE;2-[3,5-DIHYDROXYPHENYL]-2-HYDROXY-2'-[4-HYDROXYPHENYL]-1'-METHYLDIETHYLAMINE HYDROBROMIDE;1-(3,5-dihydroxy-phenyl)-2-((1-(4-hydroxybenzyl)ethyl)amino)-ethanolhydrobro;berotec;berotechydrobromide;fenoterolbromide;partusisten |
CAS号 | 1944-12-3 |
分子式 | C17H21NO4.BrH |
分子量 | 384.27 |
EINECS号 | 217-742-8 |
相关类别 | 分析标准品;瘦肉精类;法医和兽医标准品;医药原料;标准品;对照品;Adrenoceptor;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 1944-12-3.mol |
结构式 |
氢溴酸非诺特罗 性质
熔点 | 226-228°C |
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储存条件 | 2-8°C |
溶解度 | 溶于水和乙醇(96%)。 |
形态 | 固体 |
颜色 | 白色至类白色 |
Target | Value |
β2 adrenoreceptor
() |
Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells.
Western Blot Analysis
Cell Line: | THP-1 cells stimulated with AICAR |
Concentration: | 1 μM |
Incubation Time: | Pre-incubated 30 minutes |
Result: | Significantly downregulated the elevated phosphorylation levels of AMPK. |
Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment.
Animal Model: | Male C57BL/6J mice (6 weeks old) with neuropathy |
Dosage: | 0.7 mg/kg |
Administration: | Intraperitoneal injection; twice a day; for 3 weeks |
Result: | Alleviated neuropathic allodynia during chronic treatment. |
安全信息
提供商 | 语言 |
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英文
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