5-氯-2-脱氧尿嘧啶核苷
中文名称 | 5-氯-2-脱氧尿嘧啶核苷 |
---|---|
中文同义词 | 5-氯-2'-脱氧尿苷;5-氯-2-脱氧尿嘧啶核苷;5-氯脱氧尿苷;5-氯-2'-脱氧尿苷/尿苷;5-CHLORO-2'-DEOXYURIDINE 5-氯-2-脱氧尿嘧啶核苷;5-氯-1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-)嘧啶-2,4(1H,3H)-二酮;5-氯-2'-脱氧尿苷 |
英文名称 | 5-CHLORO-2'-DEOXYURIDINE |
英文同义词 | 2'-DEOXY-5-CHLOROURIDINE;5-CHLORODESOXYURIDINE;5-CHLORO-2'-DEOXYURIDINE;5-chloro-2’-deoxy-uridin;5-Chlorodeoxyuridin;5-Chloro-2'-deoxy-D-uridine;5-CHLORODEOXYURIDINE;Chlorodeoxyuridine |
CAS号 | 50-90-8 |
分子式 | C9H11ClN2O5 |
分子量 | 262.65 |
EINECS号 | |
相关类别 | 核苷;API intermediates;Bases & Related Reagents;Carbohydrates & Derivatives;Heterocycles;Nucleotides;Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides |
Mol文件 | 50-90-8.mol |
结构式 |
5-氯-2-脱氧尿嘧啶核苷 性质
熔点 | 176-179°C |
---|---|
密度 | 1.5507 (rough estimate) |
折射率 | 1.6500 (estimate) |
储存条件 | -20°C |
溶解度 | DMSO(少许)、甲醇(少许)、水(少许) |
形态 | 固体 |
酸度系数(pKa) | 7.73±0.10(Predicted) |
颜色 | 白色至类白色 |
CAS 数据库 | 50-90-8(CAS DataBase Reference) |
When 5-Chloro-2’-deoxyuridine (ClDU) is placed into tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In the studies reported here, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase.
安全信息
危险品标志 | Xn |
---|---|
危险类别码 | 20/21/22-40 |
安全说明 | 36/37/39-45 |
WGK Germany | 3 |
RTECS号 | YU7400000 |
海关编码 | 29349990 |
提供商 | 语言 |
---|---|
英文
|