4-羟基壬烯醛
中文名称 | 4-羟基壬烯醛 |
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中文同义词 | 4-羟基壬烯醛;(E)-4-羟基-2-壬烯醛;4-羟基壬醛;干冰运输]4-羟基壬烯醛;鱼4-羟基壬烯酸(4-HNE)ELISA试剂盒;ANTI-4 HYDROXYNONENAL ANTIBODY-4-羟基壬烯醛抗体;AF647标记的4-羟基壬烯醛抗体;PE标记的4-羟基壬烯醛抗体 |
英文名称 | HNE |
英文同义词 | Ccris 1781;(E)-4-HYDROXYNONENAL;HNE;(+/-)-4-HYDROXY-2E-NONENAL;(+/-)-4-HYDROXYNON-2-ENAL;4-hydroxy-2-nonena;2-Nonenal, 4-hydroxy-, (2E)-;Mouse 4-Hydroxy-2-nonenal elisa kit |
CAS号 | 75899-68-2 |
分子式 | C9H16O2 |
分子量 | 156.22 |
EINECS号 | |
相关类别 | 生化试剂;试剂盒-Elisa试剂盒;小分子 |
Mol文件 | 75899-68-2.mol |
结构式 |
4-羟基壬烯醛 性质
沸点 | 125-127 °C(Press: 2 Torr) |
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密度 | 0.941±0.06 g/cm3(Predicted) |
储存条件 | -70°C |
溶解度 | DMF:>50mg/mL; DMSO:>50mg/mL;乙醇:>50mg/mL; PBS pH 7.2:>1 mg/mL |
酸度系数(pKa) | 13.31±0.20(Predicted) |
形态 | 无色油状物。 |
CAS 数据库 | 75899-68-2(CAS DataBase Reference) |
Human Endogenous Metabolite
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4-Hydroxynonenal is both a substrate and an inhibitor of ALDH2; inhibition of ALDH2 by 4-Hydroxynonenal is reversible at low concentration and become irreversible when the concentration of 4-HNE reaches 10 µM.
4-Hydroxynonenal can induce antioxidant defense mechanisms to restrain its own production and to enhance the cellular protection against oxidative stress.
4-Hydroxynonenal, the product of lipid peroxidation, is mutagenic and genotoxic in viruses, bacteria and mammalian cells. It reacts with all four DNA bases but with different efficiency: G >C > A >T. 4-Hydroxynonenal-dG represents the best biomarker of the genotoxic effects of 4-Hydroxynonenal and these adducts are primarily found in nuclear DNA. A classic example of etiological relevance of 4-Hydroxynonenal-dG in human cancers is 4-Hydroxynonenal-dG induced p53 mutation. 4-Hydroxynonenal-dG adducts were preferentially formed at the third base of codon 249 in the p53 gene, causing gene mutation and affecting diverse biological processes including cell cycle arrest, apoptosis, DNA repair, and differentiation.
Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2 +/+ ) and Nrf2-deficient mice (Nrf2 −/− ) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2 +/+ and Nrf2 −/− mice. Similar to iNOS result, in Nrf2 −/− KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2 +/+ WT animals.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-113466 | 4-Hydroxynonenal | 1 mg | 480元 | |
2024/01/25 | HY-113466 | 4-羟基壬烯醛 4-Hydroxynonenal | 75899-68-2 | 5 mg | 1200元 |