2-((1-((3',6'-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18-PENTAOXA-2-AZAHENICOSAN-21-YL)AMINO)-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)BENZAMIDE,HS-27
生物活性靶点体外研究 用途与合成方法 MSDS 2-((1-((3',6'-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18-PENTAOXA-2-AZAHENICOSAN-21-YL)AMINO)-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)BENZAMIDE,HS-27价格(试剂级) 上下游产品信息
| 中文名称 | 2-((1-((3',6'-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18-PENTAOXA-2-AZAHENICOSAN-21-YL)AMINO)-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)BENZAMIDE,HS-27 |
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| 中文同义词 | HS27 人皮肤成纤维细胞系;人包皮皮肤成纤维细胞;2-((1-((3',6'-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18;化合物HS-27;HS27人皮肤成纤维细胞 |
| 英文名称 | Hs 27 |
| 英文同义词 | Hs 27;1562024-11-7;2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thio,HS-27;Benzamide, 2-[[21-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)amino]-21-thioxo-4,7,10,13,16-pentaoxa-20-azaheneicos-1-yl]amino]-4-(4,5,6,7-tetrahydro-3,6,6-trimethyl-4-oxo-1H-indazol-1-yl)-;HS27;HS-27;HS 27;2-((1-((3',6'-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18-PENTAOXA-2-AZAHENICOSAN-21-YL)AMINO)-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)BENZAMIDE,HS-27;HS27,HS 27;2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thioxo-6,9,12,15,18-pentaoxa-2-azahenicosan-21-yl)amino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide,HS-27 |
| CAS号 | 1562024-11-6 |
| 分子式 | C52H60N6O12S |
| 分子量 | 993.13 |
| EINECS号 | |
| 相关类别 | 生物试剂;细胞-细胞系 |
| Mol文件 | 1562024-11-6.mol |
| 结构式 | ![2-((1-((3',6'-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18-PENTAOXA-2-AZAHENICOSAN-21-YL)AMINO)-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)BENZAMIDE,HS-27 结构式](CAS/20200611/GIF/1562024-11-6.gif) |
2-((1-((3',6'-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18-PENTAOXA-2-AZAHENICOSAN-21-YL)AMINO)-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)BENZAMIDE,HS-27 性质
| 沸点 | 1095.1±75.0 °C(Predicted) |
|---|---|
| 密度 | 1.39±0.1 g/cm3(Predicted) |
| 储存条件 | -196°C |
| 溶解度 | 二甲基亚砜：125 mg/mL（125.86 mM） |
| 酸度系数(pKa) | 9.33±0.20(Predicted) |
2-((1-((3',6'-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18-PENTAOXA-2-AZAHENICOSAN-21-YL)AMINO)-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)BENZAMIDE,HS-27 用途与合成方法
HS-27，一种荧光 Hsp90 抑制剂，检测完整组织标本表面 Hsp90 的表达。HS-27 由 SNX-5422 的核心元素组成，SNX-5422 是一种 Hsp90 抑制剂，通过 PEG 连接物与荧光素衍生物 (异硫氰酸荧光素或 FITC) 连接，后者与外周表达的 Hsp90 结合。HS-27 在乳腺癌的观察与研究中有潜在的应用。
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HSP90
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HS-27 labels all receptor subtypes of breast cancer, but not normal cells, and specifically binds to Hsp90 expressed on the surface of breast cancer cells before being internalized. HS-27 fluorescence is greater in tumor than non-tumor tissue.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-130851 | HS-27 | 1 mg | 1400元 | |
| 2024/04/30 | HY-130851 | 2-((1-((3',6'-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18-PENTAOXA-2-AZAHENICOSAN-21-YL)AMINO)-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)BENZAMIDE,HS-27 HS-27 | 1562024-11-6 | 5mg | 3500元 |