| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:PF-4191834 >=98% (HPLC)
CAS:1029317-21-2
Purity:NULL Package:1ea;25mg;5mg Remarks:NULL
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| | PF04191834 Basic information |
| Product Name: | PF04191834 | | Synonyms: | PF04191834;PF-4191834;2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio]phenyl]-;PF-4191834 >=98% (HPLC);PF4191834,Lipoxygenase,PF 4191834,inhibit,LOX,PF 04191834,PF-4191834,PF04191834,Inhibitor | | CAS: | 1029317-21-2 | | MF: | C22H23N3O2S | | MW: | 393.5 | | EINECS: | | | Product Categories: | | | Mol File: | 1029317-21-2.mol |  |
| | PF04191834 Chemical Properties |
| Melting point | 173 °C | | Boiling point | 663.0±55.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 15.78±0.20(Predicted) |
| | PF04191834 Usage And Synthesis |
| Biological Activity | PF-4191834 (PF-04191834) is an orally active, non-iron-chelating, non-redox 5-lipoxygenase (5-LOX) inhibitor (IC50=229 nM), 5-LOX is about 300 times more selective than 12-LOX and 15-LOX, has no activity against cyclooxygenase, and is effective against inflammation and pain. | | in vitro | PF-4191834 (PF-04191834) inhibits the synthesis of the 5-LOX products 5-HETE, 5-oxo-ETE, LTB4, and LTE4 with estimated IC 50 values between 100 and 190 nM and do not inhibit significantly the COX-1/2 enzymes or the 12- or 15-LOX enzymes at concentrations up to 30 μM. PF-4191834 (PF-04191834) exerts a concentration-dependent inhibition of human 5-LOX, with an IC 50 value of 130 nM and an IC 80 value of 370 nM. | | target | |
| | PF04191834 Preparation Products And Raw materials |
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