人参皂甙 Rh1
中文名称 | 人参皂甙 Rh1 |
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中文同义词 | 人参皂苷-RH1;人参皂苷 S-RH1;人参皂苷RH1(标准品);人参皂苷RH1(S)/20(S)-人参皂苷RH1;(R型)人参皂苷RH1;人参皂荚RH1;(S型)人参皂苷RH1;人参皂苷RH1(S) |
英文名称 | Ginsenoside Rh1 |
英文同义词 | sanchinoside rh1;(3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl?beta-d-glucopyranoside;GINSENOSIDE RH1;(20S)-6α-(β-D-Glucopyranosyloxy)-3β,12β,20-trihydroxydammara-24-ene;(20S)-6α-(β-D-Glucopyranosyloxy)dammar-24-ene-3β,12β,20-triol;3β,12β,20-Trihydroxy-5α-dammar-24-en-6α-yl β-D-glucopyranoside;6α-(β-D-Glucopyranosyloxy)-dammara-24-ene-3β,12β,20-triol;GINSENOSIDE Rh1(SH) |
CAS号 | 63223-86-9 |
分子式 | C36H62O9 |
分子量 | 638.88 |
EINECS号 | |
植物来源 | 人参 |
相关类别 | 中药对照品;标准品;生化试剂;对照品,标准品;分析标准品;植物提取物;Ginsenoside series;对照品;植提标准品;小分子抑制剂;小分子抑制剂,天然产物;中药标准品;化学试剂;生化试剂-其他化学试剂;标准品-中药标准品;标准品 -中药标准品;三萜;分析试剂-对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors |
Mol文件 | 63223-86-9.mol |
结构式 |
人参皂甙 Rh1 性质
沸点 | 755.1±60.0 °C(Predicted) |
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密度 | 1.23 |
储存条件 | 2-8°C |
溶解度 | DMSO:100 mg/mL(156.53 mM;需要超声波) |
形态 | 粉末 |
酸度系数(pKa) | 12.91±0.70(Predicted) |
颜色 | 白色 |
LogP | 3.740 (est) |
PPAR-γ
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TNF-α
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IL-6
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IL-1β
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Human Endogenous Metabolite
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The effect of Ginsenoside Rh1 is examined on adipogenesis in 3T3-L1 cells. Ginsenoside Rh1 potently inhibits the adipogenesis, as assessed by Oil-red O staining and lipid contents in 3T3-L1 adipocytes. Ginsenoside Rh1, at concentrations of 50 μM and 100 μM, inhibit the adipogenesis by 50% and 63%, respectively.The expression levels of adipocytespecific genes such as PPAR-γ, C/EBP-α, FAS, aFABP and some genes are examined during early phase of differentiation such as Pref-1, C/EBP-δ and Glucocorticoid receptor (GR). After the treatment with Ginsenoside Rh1 in 3T3-L1 cells, mRNA is extracted on 18 h and 24 h for Pref-1, C/EBP-δ and GR and day 8 for PPAR-γ, C/EBP-α, FAS, aFABP. Then, the expression profiles of adipocyte-specific genes are investigated by RT-PCR. PPAR-γ, C/EBP-α, FAS, and aFABP expressions are significantly increased in DMI-stimulated differentiated adipocyte compared to those of non-stimulated adipocyte cells. However, treatment with DMI in the presence of Ginsenoside Rh1 significantly suppresses the expression levels of PPAR-γ, C/EBP-α, FAS, and aFABP in a dose- dependent manner, whereas the expression levels of Pref-1, C/EBP-δ and GR are not affected.
When high-fat diet (HFD) fed mice for 8 weeks, body and epididymal fat weight gains are significantly increased compared to those of low-fat diet (LFD)-fed mice. However, when Ginsenoside Rh1 is treated in HFD-fed mice, body and epididymal fat weight gains are significantly decrease compared with those of the HFD-fed mice. TG, glucose, insulin, total cholesterol, and HDL levels in the blood are significantly increased in HFD-fed mice group compared to LFD-fed mice group. Treatment with Ginsenoside Rh1 in HFD-fed mice significantly lowers TG level alone.
药理药效:具有滋补强壮,抗肿瘤作用。
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N0604 | 人参皂甙 Rh1 Ginsenoside Rh1 | 63223-86-9 | 5mg | 400元 |
2024/08/19 | HY-N0604 | 人参皂甙 Rh1 Ginsenoside Rh1 | 63223-86-9 | 10mM * 1mLin DMSO | 560元 |