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2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:RN-1734
CAS:946387-07-1
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
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Products Intro: Product Name:2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
CAS:946387-07-1
Purity:95%~99.99% heidi@coreychem.com Package:1KG;2.8USD
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Products Intro: Product Name:2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
CAS:946387-07-1
Package:1g; 5g; 25g; 1kg; 5kg; 25kg
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:RN-1734
CAS:946387-07-1
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
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Products Intro: Product Name:2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
CAS:946387-07-1
Purity:98% Package:25mg, 50mg, 100mg, 5mg, 10mg
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Basic information
Product Name:2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
Synonyms:2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide;RN 1734;2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734);2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide;TRPV4 Antagonist I, RN-1734;TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem;2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide;Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-
CAS:946387-07-1
MF:C14H22Cl2N2O2S
MW:353.31
EINECS:
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Mol File:946387-07-1.mol
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Structure
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Chemical Properties
storage temp. 2-8°C
solubility DMSO: >20mg/mL
form Yellow solid
color white to off-white
Safety Information
WGK Germany nwg
MSDS Information
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Usage And Synthesis
UsesRN 1734 is a novel TRPV4 modulator.
UsesRN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.
General DescriptionA cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 μM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 μM).
Biological ActivitySelective TRPV4 antagonist (IC 50 values are 2.3, 5.9 and 3.2 μ M for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Displays selectivity for over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).
Biochem/physiol ActionsRN-1734 is a selective TRPV4 antagonist.
storage+4°C
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Preparation Products And Raw materials
Tag:2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide(946387-07-1) Related Product Information
5-METHYL-N,N-DIMETHYLTRYPTAMINE Cumene N-Isopropylacrylamide N-Isopropylbenzylamine N-Methyl-2-pyrrolidone RN-1 (hydrochloride) RKI1447 RN486